Cancer Immunoediting: Integrating Immunity's Roles in Cancer Suppression and Promotion

被引：4764
作者：
Schreiber, Robert D. [1 ]
Old, Lloyd J. [2 ]
Smyth, Mark J. [3 ,4 ]
机构：
[1] Washington Univ, Sch Med, Dept Pathol & Immunol, St Louis, MO 63110 USA
[2] Mem Sloan Kettering Canc Ctr, Ludwig Inst Canc Res, New York Branch, New York, NY 10021 USA
[3] Peter MacCallum Canc Ctr, Canc Immunol Program, Melbourne, Vic 3002, Australia
[4] Univ Melbourne, Dept Pathol, Parkville, Vic 3010, Australia
来源：
SCIENCE | 2011年 / 331卷 / 6024期
基金：
英国医学研究理事会;
关键词：
TUMOR-INFILTRATING LYMPHOCYTES; T-CELL RESPONSES; IFN-GAMMA; IMMUNOSURVEILLANCE; INFLAMMATION; SURVEILLANCE; MELANOMA; SYSTEM; IMMUNOLOGY; REJECTION;
D O I：
10.1126/science.1203486
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Understanding how the immune system affects cancer development and progression has been one of the most challenging questions in immunology. Research over the past two decades has helped explain why the answer to this question has evaded us for so long. We now appreciate that the immune system plays a dual role in cancer: It can not only suppress tumor growth by destroying cancer cells or inhibiting their outgrowth but also promote tumor progression either by selecting for tumor cells that are more fit to survive in an immunocompetent host or by establishing conditions within the tumor microenvironment that facilitate tumor outgrowth. Here, we discuss a unifying conceptual framework called "cancer immunoediting," which integrates the immune system's dual host-protective and tumor-promoting roles.
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收藏
页码：1565 / 1570
页数：6
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