Anthelmintic efficiency of doramectin, fenbendazole, and nitroxynil, in combination or individually, in sheep worm control

被引：9

作者：

Holsback, Luciane ^{[1
]}

Ramsey Luppi, Pedro Alex ^{[2
]}

Silva, Camile Sanches ^{[3
]}

Negrao, Gustavo Kremer ^{[2
]}

Conde, Gabriel ^{[2
]}

Gabriel, Hugo Vinicius ^{[2
]}

Balestrieri, Joao Vitor ^{[2
]}

Tomazella, Lucas ^{[2
]}

机构：

[1] UENP, Setor Vet Prod Anim, Bandeirantes, PR, Brazil

[2] UENP, Campus Luiz Meneghel,Rodovia BR 369,Km 54, BR-86360000 Bandeirantes, PR, Brazil

[3] Univ Fed Mato Grosso Sul UFMS, Campo Grande, MS, Brazil

来源：

REVISTA BRASILEIRA DE PARASITOLOGIA VETERINARIA | 2016年 / 25卷 / 03期

关键词：

Parasitic resistance; Haemonchus; Cooperia; small ruminants; anthelmintic association; RESISTANT NEMATODES; IVERMECTIN; PHARMACOKINETICS; TELADORSAGIA; MOXIDECTIN;

D O I：

10.1590/S1984-29612016025

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ; 100103 ;

摘要：

The anthelmintic efficiency of doramectin, fenbendazole, and nitroxynil, used individually or in combination, was determined by the Fecal Egg Count Reduction (FECR) test and cultivation of larvae of anthelminthic-treated sheep grouped as follows: G1 (doramectin), G2 (fenbendazole), G3 (nitroxynil), G4 (doramectin + fenbendazole), G5 (doramectin + nitroxynil), G6 (fenbendazole + nitroxynil), G7 (doramectin + nitroxynil + fenbendazole), G8 (untreated). In addition to individually used doramectin and fenbendazole, the helminths were also resistant to the combination of doramectin + fenbendazole; nitroxynil + fenbendazole; and doramectin + nitroxynil + fenbendazole, with their FECR rates ranging from 62-83%. The helminths showed possible nitroxynil-resistance, but had low resistance when the drug was administered in combination with doramectin. The evaluation of individual helminth species revealed that fenbendazole was fully effective against Cooperia; doramectin (G1), moderately effective against Haemonchus and insufficiently active against Cooperia; nitroxynil, effective against Haemonchus and insufficiently active against Cooperia. It was concluded from the results that herd nematodes are resistant to doramectin, fenbendazole, and nitroxynil, and that the combined use of the drugs not only fails to significantly improve the anthelmintic efficiency against Haemonchus and Cooperia, but is also cost-ineffective.

引用

页码：353 / 358

页数：6

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