Cancer metabolism: The Warburg effect today

被引：207
作者：
Ferreira, Leonardo M. R. [1 ,2 ,3 ]
机构：
[1] Univ Coimbra, Dept Ciencias Vida, Fac Ciencias & Tecnol, P-3001401 Coimbra, Portugal
[2] Univ Coimbra, Unidade Quim Fis Mol, Fac Ciencias & Tecnol, P-3001401 Coimbra, Portugal
[3] Univ Coimbra, Ctr Estudos Farmaceut, Quim Farmaceut Lab, Fac Farm, P-3000548 Coimbra, Portugal
来源：
EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2010年 / 89卷 / 03期
关键词：
Cancer; Warburg effect; Metabolism; Microenvironment; MITOCHONDRIAL-DNA MUTATIONS; ENDOTHELIAL GROWTH-FACTOR; LACTIC-ACID; CARBOHYDRATE-METABOLISM; OXIDATIVE STRESS; CELL-METABOLISM; RESPIRATORY IMPAIRMENT; AEROBIC GLYCOLYSIS; LACTATE PRODUCTION; MAXIMUM ACTIVITIES;
D O I：
10.1016/j.yexmp.2010.08.006
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
One of the first studies on the energy metabolism of a tumour was carried out, in 1922, in the laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic pattern, characterized by a shift from respiration to fermentation, which has been later named the Warburg effect. Considerable work has been done since then, deepening our understanding of the process, with consequences for diagnosis and therapy. This review presents facts and perspectives on the Warburg effect for the 21st century. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：372 / 380
页数：9
相关论文
共 50 条
  • [41] Fructose contributes to the Warburg effect for cancer growth
    Nakagawa, Takahiko
    Lanaspa, Miguel A.
    San Millan, Inigo
    Fini, Mehdi
    Rivard, Christopher J.
    Sanchez-Lozada, Laura G.
    Andres-Hernando, Ana
    Tolan, Dean R.
    Johnson, Richard J.
    CANCER & METABOLISM, 2020, 8 (01)
  • [42] Pseudohypoxia, Mitochondrial Mutations, the Warburg Effect, and Cancer
    Sanders, Edward
    BIOMEDICAL RESEARCH-INDIA, 2012, 23 : 109 - 131
  • [43] Revisiting the Warburg Effect: Diet-Based Strategies for Cancer Prevention
    Tran, Quangdon
    Lee, Hyunji
    Kim, Chaeyeong
    Kong, Gyeyeong
    Gong, Nayoung
    Kwon, So Hee
    Park, Jisoo
    Kim, Seon-Hwan
    Park, Jongsun
    BIOMED RESEARCH INTERNATIONAL, 2020, 2020
  • [44] The Warburg Effect: Persistence of Stem Cell Metabolism in Lung Cancer as Failure of Differentiation
    Downey, Robert
    Riester, Markus
    Wu, Hua-Jun
    Zheng, Junting
    Michor, Franziska
    JOURNAL OF THORACIC ONCOLOGY, 2017, 12 (01) : S543 - S544
  • [45] Metabolic changes in cancer: beyond the Warburg effect
    Wu, Weihua
    Zhao, Shimin
    ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2013, 45 (01) : 18 - 26
  • [46] Exploring the mystery of tumor metabolism: Warburg effect and mitochondrial metabolism fighting side by side
    Yu, Yongxin
    Jiang, Yulang
    Glandorff, Christian
    Sun, Mingyu
    CELLULAR SIGNALLING, 2024, 120
  • [47] Modeling Core Metabolism in Cancer Cells: Surveying the Topology Underlying the Warburg Effect
    Resendis-Antonio, Osbaldo
    Checa, Alberto
    Encarnacion, Sergio
    PLOS ONE, 2010, 5 (08):
  • [48] The epigenetic basis of the Warburg effect
    Wang, Xian
    Jin, Hongchuan
    EPIGENETICS, 2010, 5 (07) : 566 - 568
  • [49] Warburg effect in Gynecologic cancers
    Kobayashi, Yusuke
    Banno, Kouji
    Kunitomi, Haruko
    Takahashi, Takayuki
    Takeda, Takashi
    Nakamura, Kanako
    Tsuji, Kosuke
    Tominaga, Eiichiro
    Aoki, Daisuke
    JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH, 2019, 45 (03) : 542 - 548
  • [50] The Warburg Effect: Is it Always an Enemy?
    Papaneophytou, Christos
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2024, 29 (12):
12345