Cancer metabolism: The Warburg effect today

被引：207
作者：
Ferreira, Leonardo M. R. [1 ,2 ,3 ]
机构：
[1] Univ Coimbra, Dept Ciencias Vida, Fac Ciencias & Tecnol, P-3001401 Coimbra, Portugal
[2] Univ Coimbra, Unidade Quim Fis Mol, Fac Ciencias & Tecnol, P-3001401 Coimbra, Portugal
[3] Univ Coimbra, Ctr Estudos Farmaceut, Quim Farmaceut Lab, Fac Farm, P-3000548 Coimbra, Portugal
来源：
EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2010年 / 89卷 / 03期
关键词：
Cancer; Warburg effect; Metabolism; Microenvironment; MITOCHONDRIAL-DNA MUTATIONS; ENDOTHELIAL GROWTH-FACTOR; LACTIC-ACID; CARBOHYDRATE-METABOLISM; OXIDATIVE STRESS; CELL-METABOLISM; RESPIRATORY IMPAIRMENT; AEROBIC GLYCOLYSIS; LACTATE PRODUCTION; MAXIMUM ACTIVITIES;
D O I：
10.1016/j.yexmp.2010.08.006
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
One of the first studies on the energy metabolism of a tumour was carried out, in 1922, in the laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic pattern, characterized by a shift from respiration to fermentation, which has been later named the Warburg effect. Considerable work has been done since then, deepening our understanding of the process, with consequences for diagnosis and therapy. This review presents facts and perspectives on the Warburg effect for the 21st century. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：372 / 380
页数：9
相关论文
共 50 条
  • [21] Succinate-Directed Approaches for Warburg Effect-Targeted Cancer Management, an Alternative to Current Treatments?
    Casas-Benito, Adrian
    Martinez-Herrero, Sonia
    Martinez, Alfredo
    CANCERS, 2023, 15 (10)
  • [22] Protein networks linking Warburg and reverse Warburg effects to cancer cell metabolism
    Johar, Dina
    Elmehrath, Ahmed O.
    Khalil, Rania M.
    Elberry, Mostafa H.
    Zaky, Samy
    Shalabi, Samy A.
    Bernstein, Larry H.
    BIOFACTORS, 2021, 47 (05) : 713 - 728
  • [23] Cancer Stem Cell Theory and the Warburg Effect, Two Sides of the Same Coin?
    Pacini, Nicola
    Borziani, Fabio
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 15 (05): : 8893 - 8930
  • [24] Glutamine metabolism and radiosensitivity: Beyond the Warburg effect
    Alden, Ryan S.
    Kamran, Mohammad Zahid
    Bashjawish, Bassel A.
    Simone, Brittany A.
    FRONTIERS IN ONCOLOGY, 2022, 12
  • [25] Fundamentals of the Warburg Effect in Cancer
    Pi Xian Zhang
    Ya Qi Xing
    Yong Dong Niu
    Journal of Nutritional Oncology, 2019, 4 (03) : 108 - 114
  • [26] The Molecular Mechanisms behind Advanced Breast Cancer Metabolism: Warburg Effect, OXPHOS, and Calcium
    Mitaishvili, Erna
    Feinsod, Hanna
    David, Zachary
    Shpigel, Jessica
    Fernandez, Chelsea
    Sauane, Moira
    de la Parra, Columba
    FRONTIERS IN BIOSCIENCE-LANDMARK, 2024, 29 (03):
  • [27] Proteomic Analysis Reveals Warburg Effect and Anomalous Metabolism of Glutamine in Pancreatic Cancer Cells
    Zhou, Weidong
    Capello, Michela
    Fredolini, Claudia
    Racanicchi, Leda
    Piemonti, Lorenzo
    Liotta, Lance A.
    Noveli, Francesco
    Petricoin, Emanuel F.
    JOURNAL OF PROTEOME RESEARCH, 2012, 11 (02) : 554 - 563
  • [28] Targeting the Warburg Effect in Cancer: Where Do We Stand?
    Barba, Ignasi
    Carrillo-Bosch, Laura
    Seoane, Joan
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2024, 25 (06)
  • [29] Phytometabolites Targeting the Warburg Effect in Cancer Cells: A Mechanistic Review
    Hasanpourghadi, Mohadeseh
    Looi, Chung Yeng
    Pandurangan, Ashok Kumar
    Sethi, Gautam
    Wong, Won Fen
    Mustafa, Mohd Rais
    CURRENT DRUG TARGETS, 2017, 18 (09) : 1086 - 1094
  • [30] Nuclear receptors and the Warburg effect in cancer
    Thorne, James L.
    Campbell, Moray J.
    INTERNATIONAL JOURNAL OF CANCER, 2015, 137 (07) : 1519 - 1527
12345