Cancer metabolism: The Warburg effect today

被引：207
作者：
Ferreira, Leonardo M. R. [1 ,2 ,3 ]
机构：
[1] Univ Coimbra, Dept Ciencias Vida, Fac Ciencias & Tecnol, P-3001401 Coimbra, Portugal
[2] Univ Coimbra, Unidade Quim Fis Mol, Fac Ciencias & Tecnol, P-3001401 Coimbra, Portugal
[3] Univ Coimbra, Ctr Estudos Farmaceut, Quim Farmaceut Lab, Fac Farm, P-3000548 Coimbra, Portugal
来源：
EXPERIMENTAL AND MOLECULAR PATHOLOGY | 2010年 / 89卷 / 03期
关键词：
Cancer; Warburg effect; Metabolism; Microenvironment; MITOCHONDRIAL-DNA MUTATIONS; ENDOTHELIAL GROWTH-FACTOR; LACTIC-ACID; CARBOHYDRATE-METABOLISM; OXIDATIVE STRESS; CELL-METABOLISM; RESPIRATORY IMPAIRMENT; AEROBIC GLYCOLYSIS; LACTATE PRODUCTION; MAXIMUM ACTIVITIES;
D O I：
10.1016/j.yexmp.2010.08.006
中图分类号：
R36 [病理学];
学科分类号：
100104 ;
摘要：
One of the first studies on the energy metabolism of a tumour was carried out, in 1922, in the laboratory of Otto Warburg. He established that cancer cells exhibited a specific metabolic pattern, characterized by a shift from respiration to fermentation, which has been later named the Warburg effect. Considerable work has been done since then, deepening our understanding of the process, with consequences for diagnosis and therapy. This review presents facts and perspectives on the Warburg effect for the 21st century. (C) 2010 Elsevier Inc. All rights reserved.
引用
收藏
页码：372 / 380
页数：9
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