ERα, A Key Target for Cancer Therapy: A Review

被引：69
作者：
Liu, Yanfang [1 ]
Ma, Hong [1 ]
Yao, Jing [1 ]
机构：
[1] Huazhong Univ Sci & Technol, Union Hosp, Tongji Med Coll, Canc Ctr, Jiefang Rd 1277, Wuhan 430022, Hubei, Peoples R China
来源：
ONCOTARGETS AND THERAPY | 2020年 / 13卷
关键词：
ER alpha; estrogen receptors; estradiol; signaling pathway; cancer; ESTROGEN-RECEPTOR-ALPHA; BREAST-CANCER; IN-VIVO; PHOSPHOPROTEOME ANALYSIS; ENDOCRINE THERAPY; MEMBRANE; BETA; EXPRESSION; RESISTANCE; PROSTATE;
D O I：
10.2147/OTT.S236532
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Estrogen receptor alpha (ER alpha) is closely associated with both hormone-dependent and hormone-independent tumors, and it is also essential for the development of these cancers. The functions of ER alpha are bi-faceted; it can contribute to cancer progression as well as cancer inhibition. Therefore, understanding ER alpha is vital for the treatment of those cancers that are closely associated with its expression. Here, we will elaborate on ER alpha based on its structure, localization, activation, modification, and mutation. Also, we will look at co-activators of ER alpha, elucidate the signaling pathway activated by ER alpha, and identify cancers related to its activation. A comprehensive understanding of ER alpha could help us to find new ways to treat cancers.
引用
收藏
页码：2183 / 2191
页数：9
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