Novel 1β-methylcarbapenems having cyclic sulfonamide moieties:: Synthesis and evaluation of in vitro antibacterial activity

被引：30
作者：
Kim, Seong Jong
Park, Hyeong Beom
Lee, Jae Seoung
Jo, Nam Hyun
Yoo, Kyung Ho
Baek, Daejin
Kang, Byoung-won
Cho, Jung-Hyuck
Oh, Chang-Hyun [1 ]
机构：
[1] Korea Inst Sci & Technol, Med Chem Res Ctr, Seoul 130650, South Korea
[2] Hanyang Univ, Dept Chem, Seoul 133791, South Korea
[3] Hanseo Univ, Dept Chem, Seosan, South Korea
[4] Dong Eui Univ, Dept Chem, Pusan, South Korea
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2007年 / 42卷 / 09期
关键词：
1; beta-methylcarbapenems; antibacterial activity; substituent effects;
D O I：
10.1016/j.ejmech.2007.02.001
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of a new series of 1 beta-methylcarbapenems having cyclic sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. A particular compound (IIIi) having 2-methyl-[1,2,6]thiadiazinan-1, 1-dioxide moiety showed the most potent antibacterial activity. (c) 2007 Elsevier Masson SAS. All rights reserved.
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页码：1176 / 1183
页数：8
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