Transcription - An integrated model of the transcription complex in elongation, termination, and editing

被引:195
作者
von Hippel, PH [1 ]
机构
[1] Univ Oregon, Inst Mol Biol, Eugene, OR 97403 USA
[2] Univ Oregon, Dept Chem, Eugene, OR 97403 USA
关键词
D O I
10.1126/science.281.5377.660
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
Recent findings now allow the development of an integrated model of the thermodynamic, kinetic, and structural properties of the transcription complex in the elongation. termination, and editing phases of transcript formation. This model provides an operational framework for placing known facts and can be extended and modified to incorporate new advances. The most complete information about transcriptional mechanisms and their control continues to come from the Escherichia coli system, upon which most of the explicit descriptions provided here are based. The transcriptional machinery of higher organisms, despite its greater inherent complexity, appears to use many of the same general principles. Thus, the Lessons of E, coli continue to be relevant.
引用
收藏
页码:660 / 665
页数:6
相关论文
共 61 条
[1]   RNA CLEAVAGE AND CHAIN ELONGATION BY ESCHERICHIA-COLI DNA-DEPENDENT RNA-POLYMERASE IN A BINARY ENZYME RNA COMPLEX [J].
ALTMANN, CR ;
SOLOWCORDERO, DE ;
CHAMBERLIN, MJ .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (09) :3784-3788
[2]  
[Anonymous], UNPUB
[3]   RNA CHAIN ELONGATION BY ESCHERICHIA-COLI RNA-POLYMERASE - FACTORS AFFECTING THE STABILITY OF ELONGATING TERNARY COMPLEXES [J].
ARNDT, KM ;
CHAMBERLIN, MJ .
JOURNAL OF MOLECULAR BIOLOGY, 1990, 213 (01) :79-108
[4]   Two conformations of RNA polymerase II revealed by electron crystallography [J].
Asturias, FJ ;
Meredith, GD ;
Poglitsch, CL ;
Kornberg, RD .
JOURNAL OF MOLECULAR BIOLOGY, 1997, 272 (04) :536-540
[5]   TRANSCRIPT CLEAVAGE FACTORS FROM ESCHERICHIA-COLI [J].
BORUKHOV, S ;
SAGITOV, V ;
GOLDFARB, A .
CELL, 1993, 72 (03) :459-466
[6]   TRANSCRIPTION TERMINATION FACTOR-RHO IS AN RNA-DNA HELICASE [J].
BRENNAN, CA ;
DOMBROSKI, AJ ;
PLATT, T .
CELL, 1987, 48 (06) :945-952
[7]  
CHAMBERLIN MJ, 1995, HARVEY LECT, V88, P1
[8]   Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 Å resolution [J].
Doublié, S ;
Tabor, S ;
Long, AM ;
Richardson, CC ;
Ellenberger, T .
NATURE, 1998, 391 (6664) :251-258
[9]  
ECHOLS H, 1991, ANNU REV BIOCHEM, V60, P477, DOI 10.1146/annurev.biochem.60.1.477
[10]   MULTIPLE RNA-POLYMERASE CONFORMATIONS AND GREA - CONTROL OF THE FIDELITY OF TRANSCRIPTION [J].
ERIE, DA ;
HAJISEYEDJAVADI, O ;
YOUNG, MC ;
VONHIPPEL, PH .
SCIENCE, 1993, 262 (5135) :867-873