Programmed Death-Ligand 1 as a Regulator of Tumor Progression and Metastasis

被引：19

作者：

Vathiotis, Ioannis A. ^{[1
,2
]}

Gomatou, Georgia ^{[1
]}

Stravopodis, Dimitrios J. ^{[3
]}

Syrigos, Nikolaos ^{[1
]}

机构：

[1] Natl & Kapodistrian Univ Athens, Dept Med, Sch Med, Athens 15772, Greece

[2] Yale Univ, Sch Med, Dept Pathol, New Haven, CT 06510 USA

[3] Natl & Kapodistrian Univ Athens, Dept Biol, Sch Med, Athens 15772, Greece

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 10期

关键词：

PD-1; PD-L1; cancer; progression; metastasis; SQUAMOUS-CELL CARCINOMA; PD-L1; EXPRESSION; CLINICAL-SIGNIFICANCE; PROGNOSTIC-SIGNIFICANCE; MESENCHYMAL TRANSITION; ANTITUMOR IMMUNITY; CANCER EXOSOMES; LUNG-CANCER; CMTM6; HETEROGENEITY;

D O I：

10.3390/ijms22105383

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Programmed cell death protein 1 (PD-1)/programmed death-ligand 1 (PD-L1) immune checkpoint has long been implicated in modeling antitumor immunity; PD-1/PD-L1 axis inhibitors exert their antitumor effects by relieving PD-L1-mediated suppression on tumor-infiltrating T lymphocytes. However, recent studies have unveiled a distinct, tumor-intrinsic, potential role for PD-L1. In this review, we focus on tumor-intrinsic PD-L1 signaling and delve into preclinical evidence linking PD-L1 protein expression with features of epithelial-to-mesenchymal transition program, cancer stemness and known oncogenic pathways. We further summarize data from studies supporting the prognostic significance of PD-L1 in different tumor types. We show that PD-L1 may indeed have oncogenic potential and act as a regulator of tumor progression and metastasis.

引用

页数：13

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