Assessment of myocardial viability with [15O]water PET: A validation study in experimental myocardial infarction

被引：19

作者：

Gronman, Maria ^{[1
]}

Tarkia, Miikka ^{[1
]}

Stark, Christoffer ^{[2
]}

Vahasilta, Tommi ^{[2
,3
,4
]}

Kiviniemi, Tuomas ^{[3
,4
]}

Lubberink, Mark ^{[5
,6
]}

Halonen, Paavo ^{[7
]}

Kuivanen, Antti ^{[7
]}

Saunavaara, Virva ^{[8
,9
]}

Tolvanen, Tuula ^{[8
,9
]}

Teuho, Jarmo ^{[1
,8
]}

Teras, Mika ^{[8
,9
]}

Savunen, Timo ^{[2
]}

Pietila, Mikko ^{[3
,4
]}

Yla-Herttuala, Seppo ^{[7
,10
]}

Roivainen, Anne ^{[1
,11
]}

Knuuti, Juhani

Saraste, Antti ^{[1
,3
,4
,8
,12
]}

机构：

[1] Univ Turku, Turku PET Ctr, Turku, Finland

[2] Univ Turku, Res Ctr Appl & Prevent Cardiovasc Med, Turku, Finland

[3] Turku Univ Hosp, Ctr Heart, Turku, Finland

[4] Univ Turku, Turku, Finland

[5] Uppsala Univ, Dept Surg Sci, Uppsala, Sweden

[6] Uppsala Univ Hosp, Dept Med Phys, Uppsala, Sweden

[7] Univ Eastern Finland, AI Virtanen Inst Mol Sci, Kuopio, Finland

[8] Turku Univ Hosp, Turku PET Ctr, Turku, Finland

[9] Turku Univ Hosp, Dept Med Phys, Turku, Finland

[10] Kuopio Univ Hosp, Ctr Heart, Kuopio, Finland

[11] Univ Turku, Turku Ctr Dis Modeling, Turku, Finland

[12] Univ Turku, Inst Clin Med, Turku, Finland

来源：

JOURNAL OF NUCLEAR CARDIOLOGY | 2021年 / 28卷 / 04期

基金：

芬兰科学院;

关键词：

Radiowater; PET; myocardial perfusion imaging; viability; myocardial infarction; PERFUSABLE TISSUE INDEX; POSITRON-EMISSION-TOMOGRAPHY; BLOOD-FLOW; HIBERNATING MYOCARDIUM; HEART-FAILURE; PIG MODEL; PERFUSION; QUANTIFICATION; REVASCULARIZATION; DYSFUNCTION;

D O I：

10.1007/s12350-019-01818-5

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Background Assessment of myocardial viability is often needed in patients with chest pain and reduced ejection fraction. We evaluated the performance of reduced resting MBF, perfusable tissue fraction (PTF), and perfusable tissue index (PTI) in the assessment of myocardial viability in a pig model of myocardial infarction (MI). Methods and results Pigs underwent resting [O-15]water PET perfusion study 12 weeks after surgical (n = 16) or 2 weeks after catheter-based (n = 4) occlusion of the proximal left anterior descending coronary artery. MBF, PTF, and PTI were compared with volume fraction of MI in matched segments as assessed by triphenyl tetrazolium chloride staining of LV slices. MBF and PTF were lower in infarcted than non-infarcted segments. Segmental analysis of MBF showed similar area under the curve (AUC) of 0.85, 0.86, and 0.90 with relative MBF, PTF, and PTI for the detection of viable myocardium defined as infarct volume fraction of < 75%. Cut-off values of relative MBF of >= 67% and PTF of >= 66% resulted in accuracies of 90% and 81%, respectively. Conclusions Our results indicate that resting MBF, PTF, and PTI based on [O-15]water PET perfusion imaging are useful for the assessment of myocardial viability.

引用

页码：1271 / 1280

页数：10

共 28 条

[1] Myocardial viability as integral part of the diagnostic and therapeutic approach to ischemic heart failure [J].