Neuromyelitis optica with clinical and histopathological involvement of the brain

被引：29

作者：

Hengstman, G. J. D.

Wesseling, P.

Frenken, C. W. G. M.

Jongen, P. J. H.

机构：

[1] Radboud Univ Nijmegen, Med Ctr, Dept Neurol 935, NL-6500 HB Nijmegen, Netherlands

[2] Multiple Sclerosis Ctr Nijmegen, Nijmegen, Netherlands

[3] Radboud Univ Nijmegen, Med Ctr, Dept Pathol, Nijmegen, Netherlands

[4] Cansius Wilhelmina Ziekenhuis, Dept Neurol, Nijmegen, Netherlands

来源：

MULTIPLE SCLEROSIS | 2007年 / 13卷 / 05期

关键词：

cerebral; devic; histopathological; neuromyelitis optica;

D O I：

10.1177/1352458506070145

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Diagnostic criteria for neuromyelitis optica (NMO) state that there should be no active disease outside the optic nerves and spinal cord. However, several cases have been described with symptomatic brain involvement. We describe an autopsy case of a patient with NMO and symptomatic involvement of the brain. The histopathology of the brain lesions is typical for NMO, with extensive macrophage infiltration, including perivascular accumulation of large numbers of eosinophils. This is the first case that clearly shows that in NMO, the histopathology of the brain lesions is identical to that of the lesions in the optic nerves and spinal cord.

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收藏

页码：679 / 682

页数：4

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