Limited efficacy of daratumumab in multiple myeloma with extramedullary disease

被引:31
作者
Jelinek, Tomas [1 ,2 ]
Sevcikova, Tereza [1 ,2 ]
Zihala, David [1 ,2 ]
Popkova, Tereza [1 ,2 ]
Kapustova, Veronika [1 ,2 ,3 ]
Broskevicova, Lucie [1 ,2 ]
Capkova, Lenka [4 ]
Rihova, Lucie [5 ]
Bezdekova, Renata [5 ]
Sevcikova, Sabina [6 ]
Zidlik, Vladimir [7 ]
Havel, Martin [8 ]
Plonkova, Hana [1 ,2 ]
Jungova, Alexandra [9 ]
Minarik, Jiri [10 ,11 ]
Stork, Martin [12 ,13 ]
Pour, Ludek [12 ,13 ]
Pavlicek, Petr [14 ]
Spicka, Ivan [15 ,16 ]
Maisnar, Vladimir [17 ]
Radocha, Jakub [17 ]
Simicek, Michal [1 ,2 ]
Hajek, Roman [1 ,2 ]
机构
[1] Univ Hosp Ostrava, Dept Hematooncol, Ostrava, Czech Republic
[2] Univ Ostrava, Fac Med, Ostrava, Czech Republic
[3] Univ Ostrava, Fac Med, Dept Biol & Ecol, Ostrava, Czech Republic
[4] Inst Biostat & Analyses Ltd, Brno, Czech Republic
[5] Univ Hosp Brno, Dept Clin Hematol, Brno, Czech Republic
[6] Masaryk Univ, Fac Med, Dept Pathofysiol, Babak Myeloma Grp, Brno, Czech Republic
[7] Univ Hosp Ostrava, Dept Pathol, Ostrava, Czech Republic
[8] Univ Hosp Ostrava, Dept Nucl Med, Ostrava, Czech Republic
[9] Charles Univ Hosp Pilsen, Hematol & Oncol Dept, Czechia, Czech Republic
[10] Univ Hosp Olomouc, Dept Hematooncol, Czechia, Czech Republic
[11] Palacky Univ Olomouc, Fac Med & Dent, Czechia, Czech Republic
[12] Univ Hosp Brno, Dept Internal Med Hematol & Oncol, Czechia, Czech Republic
[13] Masaryk Univ, Fac Med, Czechia, Czech Republic
[14] Univ Hosp Kralovske Vinohrady, Dept Internal Med & Hematol, Prague, Czech Republic
[15] Charles Univ Prague, Fac Med 1, Clin Dept Haematol, Med Dept 1, Prague, Czech Republic
[16] Charles Univ Prague, Gen Teaching Hosp, Prague, Czech Republic
[17] Charles Univ Prague, Univ Hosp Hradec Kralove, Fac Med Hradec Kralove, Dept Internal Med Hematol 4, Hradec Kralove, Czech Republic
关键词
D O I
10.1038/s41375-021-01343-w
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
[No abstract available]
引用
收藏
页码:288 / 291
页数:4
相关论文
共 15 条
  • [1] Targeting DNA Methylation and EZH2 Activity to Overcome Melanoma Resistance to Immunotherapy
    Al Emran, Abdullah
    Chatterjee, Aniruddha
    Rodger, Euan J.
    Tiffen, Jessamy C.
    Gallagher, Stuart J.
    Eccles, Michael R.
    Hersey, Peter
    [J]. TRENDS IN IMMUNOLOGY, 2019, 40 (04) : 328 - 344
  • [2] Daratumumab plus lenalidomide and dexamethasone in relapsed/refractory multiple myeloma: extended follow-up of POLLUX, a randomized, open-label, phase 3 study
    Bahlis, Nizar J.
    Dimopoulos, Meletios A.
    White, Darrell J.
    Benboubker, Lotfi
    Cook, Gordon
    Leiba, Merav
    Ho, P. Joy
    Kim, Kihyun
    Takezako, Naoki
    Moreau, Philippe
    Kaufman, Jonathan L.
    Krevvata, Maria
    Chiu, Christopher
    Qin, Xiang
    Okonkwo, Linda
    Trivedi, Sonali
    Ukropec, Jon
    Qi, Ming
    San-Miguel, Jesus
    [J]. LEUKEMIA, 2020, 34 (07) : 1875 - 1884
  • [3] Beksac M., 2020, ISATUXIMAB PLUS POMA
  • [4] Extramedullary multiple myeloma
    Bhutani, Manisha
    Foureau, David M.
    Atrash, Shebli
    Voorhees, Peter M.
    Usmani, Saad Z.
    [J]. LEUKEMIA, 2020, 34 (01) : 1 - 20
  • [5] DNA methyltransferase inhibitors upregulate CD38 protein expression and enhance daratumumab efficacy in multiple myeloma
    Choudhry, Priya
    Mariano, Margarette C.
    Geng, Huimin
    Martin, Thomas G., III
    Wolf, Jeffrey L.
    Wong, Sandy W.
    Shah, Nina
    Wiita, Arun P.
    [J]. LEUKEMIA, 2020, 34 (03) : 938 - 941
  • [6] Multiple Myeloma: EHA-ESMO Clinical Practice Guidelines for Diagnosis, Treatment and Follow-up
    Dimopoulos, Meletios A.
    Moreau, Philippe
    Terpos, Evangelos
    Mateos, Maria-Victoria
    Zweegman, Sonja
    Cooks, Gordon
    Delforge, Michel
    Hajek, Roman
    Schjesvold, Fredrik
    Cavo, Michele
    Goldschmidt, Hartmut
    Facon, Thierry
    Einsele, Hermann
    Boccadoro, Mario
    San-Miguel, Jesus
    Sonneveld, Pieter
    Mey, Ulrich
    [J]. HEMASPHERE, 2021, 5 (02):
  • [7] Impact of extramedullary disease in patients with newly diagnosed multiple myeloma undergoing autologous stem cell transplantation: a study from the Chronic Malignancies Working Party of the EBMT
    Gagelmann, Nico
    Eikema, Diderik-Jan
    Iacobelli, Simona
    Koster, Linda
    Nahi, Hareth
    Stoppa, Anne-Marie
    Masszi, Tamas
    Caillot, Denis
    Lenhoff, Stig
    Udvardy, Miklos
    Crawley, Charles
    Arcese, William
    Mariette, Clara
    Hunter, Ann
    Leleu, Xavier
    Schipperus, Martin
    Delforge, Michel
    Pioltelli, Pietro
    Snowden, John A.
    Itala-Remes, Maija
    Musso, Maurizio
    van Biezen, Anja
    Garderet, Laurent
    Kroger, Nicolaus
    [J]. HAEMATOLOGICA, 2018, 103 (05) : 890 - 897
  • [8] Monoclonal antibodies - A new era in the treatment of multiple myeloma
    Jelinek, Tomas
    Hajek, Roman
    [J]. BLOOD REVIEWS, 2016, 30 (02) : 101 - 110
  • [9] The Mechanism of Action of the Anti-CD38 Monoclonal Antibody Isatuximab in Multiple Myeloma
    Moreno, Laura
    Perez, Cristina
    Zabaleta, Aintzane
    Manrique, Irene
    Alignani, Diego
    Ajona, Daniel
    Blanco, Laura
    Lasa, Marta
    Maiso, Patricia
    Rodriguez, Idoia
    Garate, Sonia
    Jelinek, Tomas
    Segura, Victor
    Moreno, Cristina
    Merino, Juana
    Rodriguez-Otero, Paula
    Panizo, Carlos
    Prosper, Felipe
    San-Miguel, Jesus F.
    Paiva, Bruno
    [J]. CLINICAL CANCER RESEARCH, 2019, 25 (10) : 3176 - 3187
  • [10] CD38 expression and complement inhibitors affect response and resistance to daratumumab therapy in myeloma
    Nijhof, Inger S.
    Casneuf, Tineke
    van Velzen, Jeroen
    van Kessel, Berris
    Axel, Amy E.
    Syed, Khaja
    Groen, Richard W. J.
    van Duin, Mark
    Sonneveld, Pieter
    Minnema, Monique C.
    Zweegman, Sonja
    Chiu, Christopher
    Bloem, Andries C.
    Mutis, Tuna
    Lokhorst, Henk M.
    Sasser, A. Kate
    van de Donk, Niels W. C. J.
    [J]. BLOOD, 2016, 128 (07) : 959 - 970