Cannabis-based medicines in multiple sclerosis - A review of clinical studies

被引：28
作者：
Rog, David J. [1 ]
机构：
[1] Greater Manchester Neurosci Ctr, Manchester M6 8HD, Lancs, England
来源：
IMMUNOBIOLOGY | 2010年 / 215卷 / 08期
关键词：
Multiple sclerosis; Cannabinoids; Cannabis-based medicines; Clinical trials; Sativex; NOCICEPTIVE FLEXION REFLEX; CHRONIC NEUROPATHIC PAIN; DOUBLE-BLIND; CONTROLLED-TRIAL; RAT MODEL; CONTROL SPASTICITY; RECEPTOR; DELTA-9-TETRAHYDROCANNABINOL; NABILONE; TETRAHYDROCANNABINOL;
D O I：
10.1016/j.imbio.2010.03.009
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
For some years a mixture of anecdotal report and data from animal models have implied a potential role for cannabis-based medicines in ameliorating a variety of symptoms of multiple sclerosis. Only recently however have large randomised controlled trials (RCTs) examined these potential effects rigorously. At present the results of RCTs have lacked a coherent message to the prescribing clinician and reasons for such heterogeneity in cannabinoid trials are discussed. (C) 2010 Elsevier GmbH. All rights reserved.
引用
收藏
页码：658 / 672
页数：15
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