Nanomedicines Targeting the Tumor Microenvironment

被引：67
作者：
Tong, Rong [1 ,2 ]
Langer, Robert [1 ]
机构：
[1] MIT, Koch Inst, Cambridge, MA 02139 USA
[2] Harvard Univ, Childrens Hosp Boston, Sch Med,Div Crit Care Med, Lab Biomat & Drug Delivery,Dept Anesthesiol, Boston, MA USA
来源：
CANCER JOURNAL | 2015年 / 21卷 / 04期
关键词：
Cancer immunology; extracellular matrix; nanomedicine; nanoparticle; near-infrared light; photothermal; stimulus-responsive drug delivery; triggered drug delivery; tumor microenvironment; tumor penetration; NEAR-INFRARED LIGHT; DRUG-DELIVERY SYSTEMS; IN-VIVO; CANCER-IMMUNOTHERAPY; EXTRACELLULAR-MATRIX; CARBON NANOTUBES; SOLID TUMORS; PHOTOSWITCHABLE NANOPARTICLES; BIOMEDICAL APPLICATIONS; PHOTOTHERMAL THERAPY;
D O I：
10.1097/PPO.0000000000000123
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We review recent progress in cancer nanomedicine to overcome the delivery barriers in tumor microenvironment, including the understanding in the nanomedicine delivery process, stimulus-responsive delivery, and several new strategies to normalize tumor microenvironment. The application of nanomedicine in cancer immunotherapy, a renewed cancer therapy by recent breakthrough, is also highlighted.
引用
收藏
页码：314 / 321
页数：8
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