NMR studies of ultrafast intramolecular proton tautomerism in crystalline and amorphous -: N,N′-diphenyl-6-aminofulvene-1-aldimine:: Solid-state, kinetic isotope, and tunneling effects

Using solid-state NMR spectroscopy, we have detected and characterized ultrafast intramolecular proton tautomerism in the N-H-N hydrogen bonds of solid N,N'-diphenyl-6-aminofulvene-1-aldimine (I) on the microsecond-to-picosecond time scale. N-15 cross-polarization magic-angle-spinning NMR experiments using H-1 decoupling performed on polycrystalline I-N-15(2) and the related compound N-phenyl-N'-(1,3,4-triazole)-6-aminofulvene-1-aldimine (II) provided information about the thermodynamics of the tautomeric processes. We found that II forms only a single tautomer but that the gas-phase degeneracy of the two tautomers of I is lifted by solid-state interactions. Rate constants, including H/D kinetic isotope effects (KIEs), on the microsecond-to-picosecond time scale were obtained by measuring and analyzing the longitudinal N-15 and H-2 relaxation times of I-N-15(2), I-N-15(2)-d(10), and I-N-15(2)-d(1) over a wide temperature range. In addition to the microcrystalline modification, a novel amorphous modification of I was found and studied. In this modification, proton transfer is much faster than in the crystalline form. For both modifications, we observed large H/D KIEs that were temperature-dependent at high temperatures and temperature-independent at low temperatures. These findings are interpreted in terms of a simple quasiclassical tunneling model proposed by Bell and modified by Limbach. We obtained evidence that a reorganization energy is necessary in order to compress the N-H-N hydrogen bond and achieve a molecular configuration in which the barrier for H transfer is reduced and tunneling or an over-barrier reaction can occur.