Poly(lactic acid) based hydrogels

被引：134
作者：
Basu, Arijit [1 ,2 ]
Kunduru, Konda Reddy [1 ,2 ]
Doppalapudi, Sindhu [3 ]
Domb, Abraham J. [1 ,2 ]
Khan, Wahid [3 ]
机构：
[1] Hebrew Univ Jerusalem, Fac Med, Sch Pharm, IL-91120 Jerusalem, Israel
[2] JCE, IL-91120 Jerusalem, Israel
[3] NIPER, Dept Pharmaceut, Hyderabad 500037, Andhra Pradesh, India
来源：
ADVANCED DRUG DELIVERY REVIEWS | 2016年 / 107卷
关键词：
PLA; PLA-PEG; Hydrogel; Thermo-responsive; In situ hydrogel; Responsive polymer; PLGA-PEG-PLGA; BIODEGRADABLE BLOCK-COPOLYMERS; SOL-GEL TRANSITION; TRIBLOCK COPOLYMERS; THERMOSENSITIVE HYDROGEL; STEREOCOMPLEX FORMATION; POLY(ETHYLENE GLYCOL); INJECTABLE HYDROGELS; CONTROLLED-RELEASE; AQUEOUS-SOLUTIONS;
D O I：
10.1016/j.addr.2016.07.004
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
Polylactide (PLA) and its copolymers are hydrophobic polyesters used for biomedical applications. Hydrogel medicinal implants have been used as drug delivery vehicles and scaffolds for tissue engineering, tissue augmentation and more. Since lactides are non-functional, they are copolymerized with hydrophilic monomers or conjugated to a hydrophilic moiety to form hydrogels. Copolymers of lactic and glycolic acids with poly(ethylene glycol) (PEG) provide thermo-responsive hydrogels. Physical crosslinking mechanisms of PEG-PLA or PLA-polysaccharides include: lactic acid segment hydrophobic interactions, stereocomplexation of D and L-lactic acid segments, ionic interactions, and chemical bond formation by radical or photo crosslinking. These hydrogels may also be tailored as stimulus responsive (pH, photo, or redox). PLA and its copolymers have also been polymerized to include urethane bonds to fabricate shape memory hydrogels. This review focuses on the synthesis, characterization, and applications of PIA containing hydrogels. (C) 2016 Elsevier B.V. All rights reserved.
引用
收藏
页码：192 / 205
页数：14
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