Induction of prolonged, continuous slow-wave sleep by blocking cerebral H1 histamine receptors in rats

被引：14

作者：

Ikeda-Sagara, Masami

Ozaki, Tomoya

Shahid, Mohammad

Morioka, Eri

Wada, Kazuma ^{[2
]}

Honda, Kazuki ^{[3
]}

Hori, Ayana ^{[4
]}

Matsuya, Yuji ^{[4
]}

Toyooka, Naoki ^{[4
]}

Ikeda, Masayuki ^{[1
,2
]}

机构：

[1] Toyama Univ, Fac Sci, Dept Biol, Grad Sch Innovat Life Sci,Gofu Ku, Toyama 9308555, Japan

[2] Toyama Univ, Grad Sch Sci & Engn, Toyama 9308555, Japan

[3] Hamri Co Ltd, Tsukuba Res Ctr, Sleep Sci Labs, Ibaraki, Japan

[4] Toyama Univ, Grad Sch Med & Pharmaceut Sci, Toyama 9308555, Japan

来源：

BRITISH JOURNAL OF PHARMACOLOGY | 2012年 / 165卷 / 01期

关键词：

continuous micro-infusion; intracellular calcium; preoptic sleep centres; second generation antihistamines; sleep encephalogram; yellow cameleon; third ventricle; FREELY MOVING RATS; IN-VITRO; MESOPONTINE TEGMENTUM; PREOPTIC HYPOTHALAMUS; BASAL FOREBRAIN; NOCTURNAL SLEEP; WAKE CONTROL; C-FOS; NEURONS; BRAIN;

D O I：

10.1111/j.1476-5381.2011.01547.x

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

BACKGROUND AND PURPOSE Classic H1 histamine receptor (H1R) antagonists are non-selective for H1R and known to produce drowsiness. Modern antihistamines are more selective for H1R, and are non-drowsy presumably due to reduced permeability through the blood-brain barrier. To characterize both histaminergic sleep regulation and the central actions of antihistamines, in the present study we analysed the effect of classic and modern antihistamines on rats' sleep using continuous i.c.v. infusions.

引用

页码：167 / 182

页数：16

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