Association between urinary dialkylphosphate metabolites and dyslexia among children from three cities of China: The READ program

被引：9

作者：

Xie, Xinyan ^{[1
,2
]}

Wan, Yanjian ^{[3
]}

Zhu, Bing ^{[4
]}

Liu, Qi ^{[1
,2
]}

Zhu, Kaiheng ^{[1
,2
]}

Jiang, Qi ^{[1
,2
]}

Feng, Yanan ^{[1
,2
]}

Xiao, Pei ^{[1
,2
]}

Wu, Xiaoqian ^{[1
,2
]}

Zhang, Jiajia ^{[5
]}

Meng, Heng ^{[1
,2
]}

Song, Ranran ^{[1
,2
]}

机构：

[1] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, Dept Maternal & Child Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China

[2] Huazhong Univ Sci & Technol, Tongji Med Coll, Sch Publ Hlth, MOE Minist Educ,Key Lab Environm & Hlth, 13 Hangkong Rd, Wuhan 430030, Hubei, Peoples R China

[3] Wuhan Ctr Dis Control & Prevent, Inst Environm Hlth, Wuhan 430024, Hubei, Peoples R China

[4] Hangzhou Ctr Dis Control & Prevent, Hangzhou, Peoples R China

[5] Univ South Carolina, Arnold Sch Publ Hlth, Dept Epidemiol & Biostat, Columbia, SC 29208 USA

来源：

SCIENCE OF THE TOTAL ENVIRONMENT | 2022年 / 814卷

基金：

中国国家自然科学基金;

关键词：

Dyslexia; Organophosphate insecticides; Diethylphosphate metabolites; Case-control study; Children; ORGANOPHOSPHATE PESTICIDE EXPOSURE; DEVELOPMENTAL DYSLEXIA; PRENATAL EXPOSURE; NEURODEVELOPMENTAL DISORDERS; PYRETHROID INSECTICIDES; GENDER-DIFFERENCES; DIETARY-INTAKE; BISPHENOL-A; BIRTH; CHLORPYRIFOS;

D O I：

10.1016/j.scitotenv.2021.151852

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Exposure to organophosphate (OP) insecticides has been found to be related to neurodevelopmental disorders in children. However, no study has examined the association between OP insecticide exposure and the risk of dyslexia among children. We aimed to explore the association between OP insecticide exposure, indicated by urinary dialkylphosphate metabolites (DAPs), and the risk of dyslexia among Chinese Han children from three cities. A total of 845 children (422 dyslexics and 423 non-dyslexics) from Tongji Reading Environment and Dyslexia research program were included in the current case-control study. We measured six DAPs in urine samples, collected from November 2017 to December 2020. Logistic regression models were used to estimate odds ratios (ORs) for the association between DAPs and dyslexia risk, adjusting for potential confounders. The detection frequencies of DAPs were above 97.5%, except for diethyldithiophosphate and dimethyldithiophosphate. Diethyl phosphate metabolites (DEs) were significantly associated with the risk of dyslexia. Compared with the lowest quartile, the adjusted ORs of dyslexia risk for the highest quartile of urinary diethylthiophosphate (DETP) and diethylphosphate (DEP) were 1.82 (1.04, 3.20) and 1.85 (1.08, 3.17), respectively. In addition, the adjusted ORs for dyslexia per 10-fold of urinary DEP, DETP, and n-ary sumation DEs concentration were 1.87 (1.12, 3.13), 1.55 (1.03, 2.35), and 1.91 (1.13, 3.21), respectively. Analyses stratified by gender indicated that such associations were more significant among boys. This study suggested that exposure to OP insecticides may be related to dyslexia among Chinese Han children from the three studied cities. However, our results should be interpreted with caution because of the case-control design and the fact that only one-spot urine sample was collected from the of children. More studies with children living in China are necessary concerning the relatively high levels of urinary OP metabolites in our study.

引用

页数：9

共 98 条

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