Assessment of endogenous dopamine release by methylphenidate challenge using iodine-123 iodobenzamide single-photon emission tomography

被引:58
作者
Booij, J [1 ]
Korn, P [1 ]
Linszen, DH [1 ]
vanRoyen, EA [1 ]
机构
[1] UNIV AMSTERDAM, ACAD MED CTR, DEPT PSYCHIAT, NL-1105 BC AMSTERDAM, NETHERLANDS
关键词
single-photon emission tomography; D-2; receptors; iodine-123; iodobenzamide; methylphenidate; constant infusion;
D O I
10.1007/BF00841408
中图分类号
R8 [特种医学]; R445 [影像诊断学];
学科分类号
1002 ; 100207 ; 1009 ;
摘要
This double-blind, placebo-controlled study assessed pharmacologically induced endogenous dopamine (DA) release in healthy male volunteers (n = 12). Changes in endogenous DA release after injection of the psychostimulant drug methylphenidate were evaluated by single-photon emission tomography (SPET) and constant infusion of iodine-123 iodobenzamide ([I-123]IBZM), a D-2 receptor radioligand that is sensitive to endogenous DA release. Methylphenidate induced displacement of striatal [I-123]IBZM binding, resulting in a significantly decrease in the specific to non-specific [I-123]IBZM uptake ratio (average: 8.6%) in comparison with placebo (average: -1.9%). Moreover, injection of methylphenidate induced significant behavioural responses on the following items: excitement, anxiety, tension, and mannerisms and posturing. The results of this study demonstrate the feasibility of using constant infusion of [I-123]IBZM and SPET imaging to measure endogenous DA release after methylphenidate challenge and to investigate neurochemical aspects of behaviour.
引用
收藏
页码:674 / 677
页数:4
相关论文
共 12 条
  • [1] [Anonymous], 1986, POSITIVE NEGATIVE SY
  • [2] A SIMPLE AND HIGH-YIELD SYNTHESIS OF (S)-BZM, (R)-BZM AND (S)-IBZM FOR THE PREPARATION OF (S)-I-123-IBZM
    BOBELDIJK, M
    VERHOEFF, NPLG
    VEKEMANS, JAJM
    BUCK, HM
    VANDOREMALEN, PAPM
    VANHOOF, JJ
    JANSSEN, AGM
    [J]. JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS, 1990, 28 (11) : 1247 - 1256
  • [3] Practical benefit of [I-123]FP-CIT SPET in the demonstration of the dopaminergic deficit in Parkinson's disease
    Booij, J
    Tissingh, G
    Winogrodzka, A
    Boer, GJ
    Stoof, JC
    Wolters, EC
    vanRoyen, EA
    [J]. EUROPEAN JOURNAL OF NUCLEAR MEDICINE, 1997, 24 (01): : 68 - 71
  • [4] FARDE L, 1992, ARCH GEN PSYCHIAT, V49, P538
  • [5] Affinities of methylphenidate derivatives for dopamine, norepinephrine and serotonin transporters
    Gatley, SJ
    Pan, DF
    Chen, RY
    Chaturvedi, G
    Ding, YS
    [J]. LIFE SCIENCES, 1996, 58 (12) : PL231 - PL239
  • [6] LARUELLE M, 1995, J NUCL MED, V36, P1182
  • [7] Single photon emission computerized tomography imaging of amphetamine-induced dopamine release in drug-free schizophrenic subjects
    Laruelle, M
    Abi-Dargham, A
    vanDyck, CH
    Gil, R
    DSouza, CD
    Erdos, J
    McCance, E
    Rosenblatt, W
    Fingado, C
    Zoghbi, SS
    Baldwin, RM
    Seibyl, JP
    Krystal, JH
    Charney, DS
    Innis, RB
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (17) : 9235 - 9240
  • [8] COCAINE RECEPTORS ON DOPAMINE TRANSPORTERS ARE RELATED TO SELF-ADMINISTRATION OF COCAINE
    RITZ, MC
    LAMB, RJ
    GOLDBERG, SR
    KUHAR, MJ
    [J]. SCIENCE, 1987, 237 (4819) : 1219 - 1223
  • [9] VERHOEFF NPLG, 1993, J NUCL MED, V34, P2076
  • [10] IMAGING ENDOGENOUS DOPAMINE COMPETITION WITH [C-11] RACLOPRIDE IN THE HUMAN BRAIN
    VOLKOW, ND
    WANG, GJ
    FOWLER, JS
    LOGAN, J
    SCHLYER, D
    HITZEMANN, R
    LIEBERMAN, J
    ANGRIST, B
    PAPPAS, N
    MACGREGOR, R
    BURR, G
    COOPER, T
    WOLF, AP
    [J]. SYNAPSE, 1994, 16 (04) : 255 - 262