Direct in vivo comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts

被引：17
|
作者：
Ioppolo, Joseph A. [1 ,2 ]
Nezich, Rikki A. [1 ,3 ]
Richardson, Kirsty L. [4 ]
Morandeau, Laurence [1 ]
Leedman, Peter J. [4 ]
Price, Roger, I [1 ,3 ]
机构：
[1] Sir Charles Gairdner Hosp, Med Technol & Phys Dept, Hosp Ave, Nedlands, WA 6009, Australia
[2] Curtin Univ, Sch Mol & Life Sci, Bentley, WA 6102, Australia
[3] Univ Western Australia, Dept Phys, Crawley, WA 6009, Australia
[4] QEII Med Ctr, Harry Perkins Inst Med Res, 6 Verdun St, Nedlands, WA 6009, Australia
来源：
APPLIED RADIATION AND ISOTOPES | 2020年 / 161卷
关键词：
AlF-PSMA-11; PSMA-1007; Ga-PSMA-11; Prostate cancer; Preclinical; IMAGING PROSTATE-CANCER; RADIATION-DOSIMETRY; PET; RADIOFLUORINATION; F-18-PSMA-1007; GA-68-PSMA-HBED-CC; BIODISTRIBUTION; VALIDATION; LIGAND; FOCUS;
D O I：
10.1016/j.apradiso.2020.109164
中图分类号：
O61 [无机化学];
学科分类号：
070301 ; 081704 ;
摘要：
The aim of this preclinical study was to directly compare [F-18]PSMA-1007 with both [Ga-68]Ga-PSMA-11 and [F-18]AlF-PSMA-11 in mice bearing PSMA-positive tumor xenografts. Uptake was assessed by PET/CT at 1, 2 and 4 h post-injection, and by ex vivo measurement after 4 h. [F-18]PSMA-1007 demonstrated the highest tumor uptake of the three tracers. The high uptake in bone for mice injected with [F-18]AlF-PSMA-11 suggested rapid in vivo decomposition. This was confirmed by an in vitro plasma stability study.
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页数：8
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