Anti-neutrophil Cytoplasmic Antibody-associated Vasculitis Superimposed on Post-streptococcal Acute Glomerulonephritis

被引：1

作者：

Kamijo, Natsumi ^{[1
]}

Mii, Akiko ^{[1
]}

Aratani, Sae ^{[1
]}

Kashiwagi, Tetsuya ^{[1
]}

Oda, Takashi ^{[2
]}

Shimizu, Akira ^{[3
]}

Sakai, Yukinao ^{[1
]}

机构：

[1] Nippon Med Sch, Dept Nephrol, Tokyo, Japan

[2] Tokyo Med Univ, Kidney Dis Ctr, Dept Nephrol & Blood Purificat, Hachioji Med Ctr, Hachioji, Japan

[3] Nippon Med Sch, Dept Analyt Human Pathol, Tokyo, Japan

来源：

INTERNAL MEDICINE | 2022年 / 61卷 / 19期

关键词：

ANCA-associated vasculitis; MPO-ANCA; neutrophil extra cellular trap; post-streptococcal acute glomerulonephritis; rapidly progressive glomerulonephritis; CRESCENTIC GLOMERULONEPHRITIS; ANCA; IMMUNE;

D O I：

10.2169/internalmedicine.8690-21

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 44-year-old woman was admitted due to gross hematuria and progressive renal dysfunction. Poststreptococcal acute glomerulonephritis (PSAGN) was suspected due to her elevated anti-streptolysin O and antistreptokinase titers and hypocomplementemia. A renal biopsy showed crescent formation and endocapillary hypercellularity with neutrophil infiltrate. An immunofluorescence analysis showed granular immunoglobulin G and C3 deposition, suggesting immune-complex-type glomerulonephritis. However, myeloperoxidase antineutrophil cytoplasmic antibody (ANCA) was positive, and peritubular capillaritis was observed. Furthermore, citrullinated histone H3-positive neutrophils were detected as markers for neutrophil extracellular trap formation. Therefore, she was diagnosed with ANCA-associated vasculitis superimposed on PSAGN that was the main contributor to her progressive renal injury.

引用

页码：2917 / 2923

页数：7

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