The Once-Daily Formulation of Tacrolimus: A Step Forward in Kidney Transplantation?

被引：25

作者：

Hougardy, Jean-Michel ^{[1
]}

de Jonge, Hylke ^{[2
]}

Kuypers, Dirk ^{[2
]}

Abramowicz, Daniel ^{[1
]}

机构：

[1] Clin Univ Hop Erasme, Dept Nephrol, Renal Transplantat Clin, B-1070 Brussels, Belgium

[2] Univ Hosp Leuven, Dept Nephrol & Renal Transplantat, Louvain, Belgium

来源：

TRANSPLANTATION | 2012年 / 93卷 / 03期

关键词：

Kidney transplantation; Tacrolimus; Formulations; PROGRAF-BASED REGIMEN; TWICE-DAILY PROGRAF; EXTENDED-RELEASE FORMULATION; 2 YEARS POSTCONVERSION; RENAL-TRANSPLANTATION; CONVERSION; RECIPIENTS; ADVAGRAF; PHARMACOKINETICS; NONADHERENCE;

D O I：

10.1097/TP.0b013e31823aa56e

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Nonadherence is a critical issue in transplantation. Recently, Astellas designed a once-daily-extended release formulation of tacrolimus (Tac). Despite initial reports showing bioequivalence of Tac once-daily (Advagraf) with the original formulation requiring twice-daily intake (Tac twice-daily, Prograf), several groups have now shown a sustained decrease in Tac exposure upon conversion from Prograf to Advagraf. Here, we discuss the possible reasons for this observation and how it could affect the expected benefits of Advagraf, and we comment on the fact that a similar lack of bioequivalence might prevail with generic immunosuppressive drugs.

引用

页码：241 / 243

页数：3

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