Correlation between the serum KL-6 level and the grade of radiation pneumonitis after stereotactic body radiotherapy for stage I lung cancer or small lung metastasis

被引：28

作者：

Iwata, Hiromitsu ^{[1
]}

Shibamoto, Yuta ^{[1
]}

Baba, Fumiya ^{[1
]}

Sugie, Chikao ^{[1
]}

Ogino, Hiroyuki ^{[1
]}

Murata, Rumi ^{[1
]}

Yanagi, Takeshi ^{[1
]}

Otsuka, Shinya ^{[1
]}

Kosaki, Katsura ^{[1
]}

Murai, Taro ^{[1
]}

Miyakawa, Akifumi ^{[1
]}

机构：

[1] Nagoya City Univ, Dept Radiol, Grad Sch Med Sci, Mizuho Ku, Nagoya, Aichi 4678601, Japan

来源：

RADIOTHERAPY AND ONCOLOGY | 2011年 / 101卷 / 02期

关键词：

KL-6; Radiation pneumonitis; Stereotactic body radiotherapy; Lung tumor; THERAPY; BIOMARKERS; TUMORS;

D O I：

10.1016/j.radonc.2011.05.031

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Serum levels of a sialylated carbohydrate antigen KL-6, a marker for interstitial pneumonitis, were serially measured before and after stereotactic body radiotherapy (SBRT) for lung tumors. It was suggested that KL-6 levels before and after SBRT would help to predict the occurrence of >= Grade 2 radiation pneumonitis. (C) 2011 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 101 (2011) 267-270

引用

收藏

页码：267 / 270

页数：4

相关论文

共 22 条

[1] Clinical outcomes of stereotactic body radiotherapy for stage I non-small cell lung cancer using different doses depending on tumor size [J].

Baba, Fumiya ;

Shibamoto, Yuta ;

Ogino, Hiroyuki ;

Murata, Rumi ;

Sugie, Chikao ;

Iwata, Hiromitsu ;

Otsuka, Shinya ;

Kosaki, Katsura ;

Nagai, Aiko ;

Murai, Taro ;

Miyakawa, Akifumi .

RADIATION ONCOLOGY, 2010, 5

[2] Stereotactic body radiotherapy for stage I lung cancer and small lung metastasis: evaluation of an immobilization system for suppression of respiratory tumor movement and preliminary results [J].

Baba, Fumiya ;

Shibamoto, Yuta ;

Tomita, Natsuo ;

Ikeya-Hashizume, Chisa ;

Oda, Kyota ;

Ayakawa, Shiho ;

Ogino, Hiroyuki ;

Sugie, Chikao .

RADIATION ONCOLOGY, 2009, 4

[3] Serum levels of KL-6 are useful biomarkers for severe radiation pneumonitis [J].

Goto, K ;

Kodama, T ;

Sekine, I ;

Kakinuma, R ;

Kubota, K ;

Hojo, F ;

Matsumoto, T ;

Ohmatsu, H ;

Ikeda, H ;

Ando, M ;

Nishiwaki, Y .

LUNG CANCER, 2001, 34 (01) :141-148

[4] Dose-response relationship for radiation-induced pneumonitis after pulmonary stereotactic body radiotherapy [J].

Guckenberger, Matthias ;

Baier, Kurt ;

Polat, Buelent ;

Richter, Anne ;

Krieger, Thomas ;

Wilbert, Juergen ;

Mueller, Gerd ;

Flentje, Michael .

RADIOTHERAPY AND ONCOLOGY, 2010, 97 (01) :65-70

[5] Serum levels of KL-6 for predicting the occurrence of radiation pneumonitis after stereotactic radiotherapy for lung tumors [J].

Hara, R ;

Itami, J ;

Komiyama, T ;

Katoh, D ;

Kondo, T .

CHEST, 2004, 125 (01) :340-344

[6] CELL MEMBRANE-ASSOCIATED MUCINS AND THEIR ADHESION-MODULATING PROPERTY [J].

HILKENS, J ;

LIGTENBERG, MJL ;

VOS, HL ;

LITVINOV, SV .

TRENDS IN BIOCHEMICAL SCIENCES, 1992, 17 (09) :359-363

[7] Dose-volume thresholds and smoking status for the risk of treatment-related pneumonitis in inoperable non-small cell lung cancer treated with definitive radiotherapy [J].

Jin, Hekun ;

Tucker, Susan L. ;

Liu, Hui Helen ;

Wei, Xiong ;

Yom, Sue Sun ;

Wang, Shulian ;

Komaki, Ritsuko ;

Chen, Yuhchyau ;

Martel, Mary K. ;

Mohan, Radhe ;

Cox, James D. ;

Liao, Zhongxing .

RADIOTHERAPY AND ONCOLOGY, 2009, 91 (03) :427-432

[8] CIRCULATING ANTIGEN-KL-6 AND LACTATE-DEHYDROGENASE FOR MONITORING IRRADIATED PATIENTS WITH LUNG-CANCER [J].

KOHNO, N ;

HAMADA, H ;

FUJIOKA, S ;

HIWADA, K ;

YAMAKIDO, M ;

AKIYAMA, M .

CHEST, 1992, 102 (01) :117-122

[9] NEW SERUM INDICATOR OF INTERSTITIAL PNEUMONITIS ACTIVITY - SIALYLATED CARBOHYDRATE ANTIGEN KL-6 [J].

KOHNO, N ;

KYOIZUMI, S ;

AWAYA, Y ;

FUKUHARA, H ;

YAMAKIDO, M ;

AKIYAMA, M .

CHEST, 1989, 96 (01) :68-73

[10]

KOHNO N, 1988, JPN J CLIN ONCOL, V18, P203