Paneth cells: Their role in innate immunity and inflammatory disease

被引：129
作者：
Elphick, DA
Mahida, YR
机构：
[1] Univ Nottingham, Queens Med Ctr, Inst Infect Immun & Inflammat, Nottingham NG7 2UH, England
[2] Univ Nottingham, Div Gastroenterol, Nottingham NG7 2UH, England
[3] Univ Hosp, Nottingham, England
来源：
GUT | 2005年 / 54卷 / 12期
关键词：
D O I：
10.1136/gut.2005.068601
中图分类号：
R57 [消化系及腹部疾病];
学科分类号：
摘要：
In this article, we discuss the current understanding of how the intestinal mucosa may exert control over luminal bacteria, and how intestinal inflammation could ensue when this control is lost. We shall review research showing how Paneth cells, and evolutionarily conserved innate immune mechanisms, are emerging as key mediators of intestinal mucosal defence.
引用
收藏
页码：1802 / 1809
页数：8
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