Background: Knowledge of changes in lymphatic flow after sentinel lymph node biopsy (SLNB) is important for the development of strategies for postoperative adjuvant therapy in malignant melanoma. Objectives: 41 patients (22 males and 19 females; average age: 67.0 +/- 24.0 years) with primary cutaneous malignant melanoma (PCMM) participated in the present study. The primary tumor sites were the upper extremities (9 patients), the lower extremities (20 patients), the trunk (11 patients) and the scalp (1 patient). The tumor thicknesses of the PCMM lesions were from 0.5 mm to 9.0 mm (average: 3.3 +/- 2.5 mm). All the participants underwent wide local excision and SLNB. Methods: We studied lymphatic flow before and after SLNB by near-infrared (NIR) imaging in all 41 cases. In addition, we performed NIR imaging of lymphatic flow after the lymph node dissection in one case with sentinel lymph node (SLN) metastasis. Results: Almost no changes in lymphatic flow were seen in 38 of the 41 patients (92.7%) after SLNB. Only in 3 patients (7.3%), one with SLN metastasis and the other two without SLN metastasis, was apparent alteration in the lymphatic flow observed after SLNB. Of the 16 patients without SLN metastasis, only 3 patients showed recurrence of the tumors. Interestingly, 1 of the 2 patients without SLN metastasis but with lymphatic flow alteration had recurrence (regional lymph node metastasis) of the melanoma, whereas only 2 of the 14 patients without SLN metastasis or lymphatic flow alteration had recurrence, 1 with regional lymph node metastasis and the other with distant lymph node metastasis. In 1 case, we reexamined the lymphatic flow after regional lymph node dissection and the lymphatic flow was found to be dramatically changed. Conclusion: We clearly demonstrated that SLNB has only a minimal effect on lymphatic flow. The present results suggest that SLNB does not increase the risk of local recurrence/in-transit metastasis and may support the efficacy of post-SLNB local adjuvant injection to prevent local recurrence and in-transit metastasis. (C) 2015 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
机构:
Hokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Aoyagi, Satoru
;
Hata, Hiroo
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Hokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Hata, Hiroo
;
Homma, Erina
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Hokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Homma, Erina
;
Shimizu, Hiroshi
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Hokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Jung, So-Youn
;
Kim, Seok-Ki
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Natl Canc Ctr, Mol Imaging & Therapy Branch, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Kim, Seok-Ki
;
Kim, Seok Won
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Kim, Seok Won
;
Kwon, Youngmee
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Kwon, Youngmee
;
Lee, Eun Sook
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Lee, Eun Sook
;
Kang, Han-Sung
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Kang, Han-Sung
;
Ko, Kyoung Lan
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Ko, Kyoung Lan
;
Shin, Kyung Hwan
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Shin, Kyung Hwan
;
Lee, Keun Seok
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Lee, Keun Seok
;
Park, In Hae
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Park, In Hae
;
Ro, Jungsil
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Ro, Jungsil
;
Jeong, Hae Jeong
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Jeong, Hae Jeong
;
Joo, Jungnam
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Natl Canc Ctr, Biometr Res Branch, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Joo, Jungnam
;
Kang, Se Hun
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Natl Canc Ctr, Mol Imaging & Therapy Branch, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Kang, Se Hun
;
Lee, Seeyoun
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
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St Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USASt Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USA
Kang, JC
;
Wanek, LA
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St Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USASt Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USA
Wanek, LA
;
Essner, R
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St Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USASt Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USA
Essner, R
;
Faries, MB
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St Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USASt Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USA
Faries, MB
;
Foshag, LJ
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St Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USASt Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USA
Foshag, LJ
;
Morton, DL
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St Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USASt Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USA
机构:
Hokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Aoyagi, Satoru
;
Hata, Hiroo
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机构:
Hokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Hata, Hiroo
;
Homma, Erina
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h-index: 0
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Hokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
Homma, Erina
;
Shimizu, Hiroshi
论文数: 0引用数: 0
h-index: 0
机构:
Hokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, JapanHokkaido Univ, Grad Sch Med, Dept Dermatol, Kita Ku, Sapporo, Hokkaido 0608638, Japan
机构:
Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Jung, So-Youn
;
Kim, Seok-Ki
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h-index: 0
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Natl Canc Ctr, Mol Imaging & Therapy Branch, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Kim, Seok-Ki
;
Kim, Seok Won
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Kim, Seok Won
;
Kwon, Youngmee
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Kwon, Youngmee
;
Lee, Eun Sook
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h-index: 0
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Lee, Eun Sook
;
Kang, Han-Sung
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h-index: 0
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Kang, Han-Sung
;
Ko, Kyoung Lan
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h-index: 0
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Ko, Kyoung Lan
;
Shin, Kyung Hwan
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Shin, Kyung Hwan
;
Lee, Keun Seok
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h-index: 0
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Lee, Keun Seok
;
Park, In Hae
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h-index: 0
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Park, In Hae
;
Ro, Jungsil
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h-index: 0
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Ro, Jungsil
;
Jeong, Hae Jeong
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h-index: 0
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Jeong, Hae Jeong
;
Joo, Jungnam
论文数: 0引用数: 0
h-index: 0
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Natl Canc Ctr, Biometr Res Branch, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Joo, Jungnam
;
Kang, Se Hun
论文数: 0引用数: 0
h-index: 0
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Natl Canc Ctr, Mol Imaging & Therapy Branch, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
Kang, Se Hun
;
Lee, Seeyoun
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h-index: 0
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Natl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South KoreaNatl Canc Ctr, Ctr Breast Canc, Goyang, Gyeonggi, South Korea
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St Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USASt Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USA
Kang, JC
;
Wanek, LA
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机构:
St Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USASt Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USA
Wanek, LA
;
Essner, R
论文数: 0引用数: 0
h-index: 0
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St Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USASt Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USA
Essner, R
;
Faries, MB
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h-index: 0
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St Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USASt Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USA
Faries, MB
;
Foshag, LJ
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h-index: 0
机构:
St Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USASt Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USA
Foshag, LJ
;
Morton, DL
论文数: 0引用数: 0
h-index: 0
机构:
St Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USASt Johns Hlth Ctr, John Wayne Canc Inst, Roy E Coats Res Labs, Santa Monica, CA 90404 USA