Synthesis of 2-aryl-5-(benzofuran-2-yl)thiazolo[3,2-b][1,2,4]triazoles using green procedures and their antibacterial activity

被引：0

作者：

Jakhar, Komal ^{[1
]}

Makrandi, J. K. ^{[1
]}

机构：

[1] Maharshi Dayanand Univ, Dept Chem, Rohtak 124001, Haryana, India

来源：

INDIAN JOURNAL OF CHEMISTRY SECTION B-ORGANIC CHEMISTRY INCLUDING MEDICINAL CHEMISTRY | 2012年 / 51卷 / 03期

关键词：

3-Aryl-5-mercapto-1,2,4-triazoles; 2-(2-bromoacetyl)benzofurans; thiazolo[3,2-b][1,2,4]triazoles; grinding technique; antibacterial activity; BRIDGEHEAD NITROGEN ATOM; SYSTEM;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

3-Aryl-5-(benzofuran-2-yl)acylthio-1,2,4-triazoles 1a-h have been prepared by condensation of 2-(2-bromoacetyl)benzofurans and various 3-aryl-5-mercapto-1,2,4-triazoles under thermal conditions as well as using microwave irradiations and grinding technique. 3-Aryl-5-(benzofuran-2-yl)acylthio-1,2,4-triazoles on cyclisation using polyphosphoric acid under microwave irradiations give 2-aryl-5-(benzofuran-2-yl)-thiazolo[3,2-b][1,2,4]triazoles 2a-h. Preparation of compounds 1a-h using grinding technique and then cyclisation to 2a-h are in accordance to green procedures as these avoid use of hazardous organic solvents during the reaction as well as at its work-up stage. The antibacterial activity of these compounds has been described.

引用

页码：531 / 536

页数：6

共 21 条

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