Dual-functional antimicrobial coating based on the combination of zwitterionic and quaternary ammonium cation from rosin acid

被引:35
作者
Chen, Chaoqi [1 ]
Li, Zhaoshuang [1 ]
Li, Xiangzhou [1 ]
Kuang, Chuntao [1 ]
Liu, Xiubo [1 ]
Song, Zhanqian [2 ]
Liu, He [2 ]
Shan, Yu [3 ]
机构
[1] Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, Hunan Prov Key Lab Mat Surface Interface Sci & Te, Changsha 410004, Peoples R China
[2] Chinese Acad Forestry, Inst Chem Ind Forestry Prod,Natl Engn Lab Biomass, Key Lab Biomass Energy & Mat,Coinnovat Ctr Effici, Key Lab Chem Engn Forest Prod,Natl Forestry & Gra, Nanjing 210042, Jiangsu, Peoples R China
[3] Jiangsu Prov & Chinese Acad Sci, Inst Bot, Nanjing 210014, Peoples R China
基金
中国国家自然科学基金;
关键词
Antimicrobial; Antibiofilm; Coating; Dopamine; Zwitterionic; Maleopimaric acid quaternary ammonium; cation; SURFACE MODIFICATION; ANTIBACTERIAL; RESISTANCE; POLYMERS; SINGLE; SALT;
D O I
10.1016/j.compositesb.2022.109623
中图分类号
T [工业技术];
学科分类号
08 ;
摘要
Treatment of implant-associated infection is becoming more challenging, especially when bacterial biofilms form on the surface of implants. To address the challenge of biofilm infection, developing dual-functional antimicrobial coatings (antimicrobial and antifouling) to combat bacterial biofilm infection are superior to those based on a single modality due to avoiding the adverse effects arising from the latter. In this work, we reported an effective dual-functional coating based on the use of synthetic terpolymers, which combined dopamine, zwitterionic 2-methacryloyloxyethyl phosphorylcholine (MPC) and maleopimaric acid quaternary ammonium cation (MPA-N+). The modified surfaces were characterized by scanning electron microscopy-energy dispersive spectroscopy (SEM-EDS), X-ray spectroscopy (XPS) and water contact angle measurements. The bactericidal efficacies of dual-functional coating were demonstrated by 1.00, 1.09 and 0.94 log reduction of Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, Pseudomonas aeruginosa, respectively, and effectively inhibited pathogenic biofilm formation. Moreover, the dual-function coating reduced protein and platelet absorption, while showing minimal cytotoxicity to the mammalian cells. Notably, an in vivo implantation model showed that the dual-functional coating eradicated the pathogenic biofilm from the implants, preventing host tissue damage and inflammation. Taken together, this dual-functional coating displayed great therapeutic potential in treating the formidable clinic problems caused by pathogenic biofilm and the accompanying inflammation.
引用
收藏
页数:11
相关论文
共 56 条
[1]   The Polymeric Matrix Composition of Vibrio cholerae Biofilms Modulate Resistance to Silver Nanoparticles Prepared by Hydrothermal Synthesis [J].
Abriat, Clemence ;
Gazil, Olivier ;
Heuzey, Marie-Claude ;
Daigle, France ;
Virgilio, Nick .
ACS APPLIED MATERIALS & INTERFACES, 2021, 13 (30) :35356-35364
[2]   Bioactive Functional Nanolayers of Chitosan-Lysine Surfactant with Single- and Mixed-Protein-Repellent and Antibiofilm Properties for Medical Implants [J].
Ajdnik, Urban ;
Zemljic, Lidija Fras ;
Plohl, Olivija ;
Perez, Lourdes ;
Trcek, Janja ;
Bracic, Matej ;
Mohan, Tamilselvan .
ACS APPLIED MATERIALS & INTERFACES, 2021, 13 (20) :23352-23368
[3]   Rapid Mussel-Inspired Surface Zwitteration for Enhanced Antifouling and Antibacterial Properties [J].
Asha, Anika Benozir ;
Chen, Yangjun ;
Zhang, Huixin ;
Ghaemi, Sina ;
Ishihara, Kazuhiko ;
Liu, Yang ;
Narain, Ravin .
LANGMUIR, 2019, 35 (05) :1621-1630
[4]   Nano Au@Cu2-xS with near-infrared photothermal and peroxidase catalytic activities redefines efficient antibiofilm-oriented root canal therapy [J].
Cao, Jun ;
Sun, Qing ;
Shen, Ai-Guo ;
Fan, Bing ;
Hu, Ji-Ming .
CHEMICAL ENGINEERING JOURNAL, 2021, 422
[5]   Light-triggerable and pH/lipase-responsive release of antibiotics and β-lactamase inhibitors from host-guest self-assembled micelles to combat biofilms and resistant bacteria [J].
Chen, Maohu ;
Qiu, Bo ;
Zhang, Zhanlin ;
Xie, Shuang ;
Liu, Yuan ;
Xia, Tian ;
Li, Xiaohong .
CHEMICAL ENGINEERING JOURNAL, 2021, 424
[6]   Bioinspired and eco-friendly high efficacy cinnamaldehyde antibacterial surfaces [J].
Cox, Harrison J. ;
Li, Jing ;
Saini, Preety ;
Paterson, Joy R. ;
Sharples, Gary J. ;
Badyal, Jas Pal S. .
JOURNAL OF MATERIALS CHEMISTRY B, 2021, 9 (12) :2918-2930
[7]   Kill-Resist-Renew Trinity: Hyperbranched Polymer with Self-Regenerating Attack and Defense for Antifouling Coatings [J].
Dai, Guoxiong ;
Ai, Xiaoqing ;
Mei, Liqin ;
Ma, Chunfeng ;
Zhang, Guangzhao .
ACS APPLIED MATERIALS & INTERFACES, 2021, 13 (11) :13735-13743
[8]   Development of a curcumin-based antifouling and anticorrosion sustainable polybenzoxazine resin composite coating [J].
Deng, Yajun ;
Xia, Lixue ;
Song, Guang-Ling ;
Zhao, Yan ;
Zhang, Yanmei ;
Xu, Yuqing ;
Zheng, Dajiang .
COMPOSITES PART B-ENGINEERING, 2021, 225 (225)
[9]   Antibacterial Liquid Metals: Biofilm Treatment via Magnetic Activation [J].
Elbourne, Aaron ;
Cheeseman, Samuel ;
Atkin, Paul ;
Truong, Nghia P. ;
Syed, Nitu ;
Zavabet, Ali ;
Mohiuddin, Md ;
Esrafilzadeh, Dorna ;
Cozzolino, Daniel ;
McConville, Chris F. ;
Dickey, Michael D. ;
Crawford, Russell J. ;
Kalantar-Zadeh, Kourosh ;
Chapman, James ;
Daeneke, Torben ;
Vi Khanh Truong .
ACS NANO, 2020, 14 (01) :802-817
[10]   Polydopamine antibacterial materials [J].
Fu, Yu ;
Yang, Lei ;
Zhang, Jianhua ;
Hu, Junfei ;
Duan, Gaigai ;
Liu, Xianhu ;
Li, Yiwen ;
Gu, Zhipeng .
MATERIALS HORIZONS, 2021, 8 (06) :1618-1633