Molecular mechanisms of drug resistance in ovarian cancer

被引：192

作者：

Norouzi-Barough, Leyla ^{[1
]}

Sarookhani, Mohammad Reza ^{[2
]}

Sharifi, Mohammadreza ^{[3
]}

Moghbelinejad, Sahar ^{[4
]}

Jangjoo, Saranaz ^{[5
]}

Salehi, Rasoul ^{[3
]}

机构：

[1] Qazvin Univ Med Sci, Sch Med, Dept Mol Med, Qazvin, Iran

[2] Qazvin Univ Med Sci, Cellular & Mol Res Ctr, Qazvin, Iran

[3] Isfahan Univ Med Sci, Sch Med, Dept Genet & Mol Biol, Esfahan 81744176, Iran

[4] Qazvin Univ Med Sci, Sch Med, Dept Biochem & Genet, Qazvin, Iran

[5] Shiraz Univ Med Sci, Sch Med, Shiraz, Iran

来源：

JOURNAL OF CELLULAR PHYSIOLOGY | 2018年 / 233卷 / 06期

关键词：

chemotherapeutic agents; drug resistance; molecular mechanisms; ovarian cancer; LONG NONCODING RNA; GLUTATHIONE-S-TRANSFERASE; EPITHELIAL-MESENCHYMAL-TRANSITION; OXYGEN SPECIES ROS; CISPLATIN RESISTANCE; CHEMOTHERAPY RESISTANCE; MULTIDRUG-RESISTANCE; ABC TRANSPORTERS; OXIDATIVE STRESS; MDR1/P-GLYCOPROTEIN EXPRESSION;

D O I：

10.1002/jcp.26289

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ovarian cancer is the most lethal malignancy among the gynecological cancers, with a 5-year survival rate, mainly due to being diagnosed at advanced stages, recurrence and resistance to the current chemotherapeutic agents. Drug resistance is a complex phenomenon and the number of known involved genes and cross-talks between signaling pathways in this process is growing rapidly. Thus, discovering and understanding the underlying molecular mechanisms involved in chemo-resistance are crucial for management of treatment and identifying novel and effective drug targets as well as drug discovery to improve therapeutic outcomes. In this review, the major and recently identified molecular mechanisms of drug resistance in ovarian cancer from relevant literature have been investigated. In the final section of the paper, new approaches for studying detailed mechanisms of chemo-resistance have been briefly discussed.

引用

页码：4546 / 4562

页数：17

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