Enveloped virus-like particle platforms: vaccines of the future?

被引：32

作者：

Pitoiset, Fabien ^{[1
]}

Vazquez, Thomas ^{[2
]}

Bellier, Bertrand ^{[3
]}

机构：

[1] Hop La Pitie Salpetriere, AP HP, Dept Inflammat Immunopathol Biotherapy I2B, Clin Invest Ctr Biotherapies CIC BTi, Paris, France

[2] INSERM, UMRS 959, Immunol Immunopathol Immunotherapy I3, F-75013 Paris, France

[3] Univ Paris 06, Sorbonne Univ, Immunol Immunopathol Immunotherapy I3, UMRS 959, F-75013 Paris, France

来源：

EXPERT REVIEW OF VACCINES | 2015年 / 14卷 / 07期

关键词：

antigen platform; retrovirus; RTS; S; vaccine development; virus-like particles; IMMUNE-RESPONSES; DNA VACCINES; MICE; INFECTION; PROTECTS; TRIAL;

D O I：

10.1586/14760584.2015.1046440

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The techniques to produce effective vaccines have evolved, and the early vaccines (live, inactivated, subunit...) are no longer considered as the most appropriate for new vaccine development. We question here what will be the future vaccines, and argue that virus-like particle (VLP)-based vaccines are promising candidates. In addition to being effective vaccines against analogous viruses from which they are derived, VLPs can also be used to present foreign epitopes to the immune system. The achievement of this strategy can be illustrated by the recent development of malaria candidate vaccine. We point out recent VLP-based vaccine developments and discuss future perspectives.

引用

页码：913 / 915

页数：3

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