The Nitric Oxide System in Equine Reproduction: Current Status and Future Directions

被引：6

作者：

Khan, Firdous A. ^{[1
]}

Scholtz, Elizabeth L. ^{[1
]}

Chenier, Tracey S. ^{[1
]}

机构：

[1] Univ Guelph, Ontario Vet Coll, Dept Populat Med, Guelph, ON N1G 2W1, Canada

来源：

JOURNAL OF EQUINE VETERINARY SCIENCE | 2015年 / 35卷 / 06期

关键词：

Nitric oxide; Stallion; Mare; Reproduction; UTERINE BLOOD-FLOW; FOLLICULAR-FLUID; LUTEAL PRODUCTION; ESTROUS-CYCLE; TNF-ALPHA; EXPRESSION; OVULATION; SYNTHASES; MARES; FOLLICLES;

D O I：

10.1016/j.jevs.2015.02.009

中图分类号：

S85 [动物医学（兽医学）];

学科分类号：

0906 ;

摘要：

The nitric oxide (NO) system is fairly ubiquitous and is involved in a wide range of physiological and pathologic processes. Besides its well-established roles in vasodilation, platelet aggregation, neurotransmission, and cytotoxicity, it has been shown to regulate reproduction in several animal species. In horses, the NO system in reproduction is a relatively recent research area. Information available in the mare is limited to the presence of the NO system in the ovaries and uterus, a possible role of the system in the regulation of normal ovarian and uterine functions, and its association with various reproductive abnormalities. Little is known about the NO system in the stallion, except for expression of nitric oxide synthase isoforms in the testis and epididymis and the effects of NO on cryopreserved semen. However, there are clear indications from research to date that NO may be an important regulator of reproduction in both stallions and mares. This review is aimed at summarizing the available information on the NO system in equine reproduction and identifying gaps in the literature that need to be addressed in the future. (C) 2015 Elsevier Inc. All rights reserved.

引用

页码：481 / 487

页数：7

共 63 条

[1] Aberrant blood flow area and plasma gonadotropin concentrations during the development of dominant-sized transitional anovulatory follicles in mares [J].

Acosta, TJ ;

Beg, MA ;

Ginther, OJ .

BIOLOGY OF REPRODUCTION, 2004, 71 (02) :637-642

[2] Nitric oxide levels and nitric oxide synthase expression in uterine samples from mares susceptible and resistant to persistent breeding-induced endometritis [J].

Alghamdi, AS ;

Foster, DN ;

Carlson, CS ;

Troedsson, MHT .

AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY, 2005, 53 (05) :230-237

[3]

Anteby EY, 1996, HUM REPROD, V11, P1947

[4]

Arruda RP, 2012, J EQUINE VET SCI, V32, P476

[5] Nitric oxide relaxes human myometrium by a cGMP-independent mechanism [J].

Bradley, KK ;

Buxton, ILO ;

Barber, JE ;

McGaw, T ;

Bradley, ME .

AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY, 1998, 275 (06) :C1668-C1673

[6] NITRIC-OXIDE MEDIATES GLUTAMATE-LINKED ENHANCEMENT OF CGMP LEVELS IN THE CEREBELLUM [J].

BREDT, DS ;

SNYDER, SH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (22) :9030-9033

[7] LEVELS OF HORMONES AND NITRIC OXIDE PRESENT IN FOLLICULAR FLUID UNDER OR NOT UNDER SUPEROVULATION IN MARES [J].

Carmo, M. T. ;

Losinno, L. ;

Aguilar, J. ;

Rose, J. ;

Araujo, G. H. M. ;

Alvarenga, M. A. .

REPRODUCTION FERTILITY AND DEVELOPMENT, 2010, 22 (01) :359-359

[8]

Carvalho HF, 2012, J EQUINE VET SCI, V32, P480

[9]

Costa A, 2006, REPROD DOMEST ANIM, V41, P361

[10] Endometrial nitric oxide production and nitric oxide synthases in the equine endometrium: Relationship with microvascular density during the estrous cycle [J].

da Costa, R. P. Roberto ;

Ferreira-Dias, G. ;

Mateus, L. ;

Korzekwa, A. ;

Andronowska, A. ;

Platek, R. ;

Skarzynski, D. J. .

DOMESTIC ANIMAL ENDOCRINOLOGY, 2007, 32 (04) :287-302

← 1 2 3 4 5 6 7 →