Ghrelin levels are reduced in Rett syndrome patients with eating difficulties

被引：9

作者：

Hara, Munetsugu ^{[1
]}

Nishi, Yoshihiro ^{[2
]}

Yamashita, Yushiro ^{[1
]}

Yoh, Junko ^{[2
]}

Takahashi, Satoru ^{[4
]}

Nagamitsu, Shin-ichiro ^{[1
]}

Kakuma, Tatsuyuki ^{[5
]}

Hosoda, Hiroshi ^{[3
]}

Kangawa, Kenji ^{[6
]}

Kojima, Masayasu ^{[5
]}

Matsuishi, Toyojiro ^{[1
]}

机构：

[1] Kurume Univ, Sch Med, Dept Pediat & Child Hlth, Kurume, Fukuoka 8300011, Japan

[2] Kurume Univ, Sch Med, Dept Physiol, Kurume, Fukuoka 8300011, Japan

[3] Asahikawa Med Univ, Dept Pediat, Asahikawa, Hokkaido 0788510, Japan

[4] Kurume Univ, Sch Med, Ctr Biostat, Kurume, Fukuoka 8300011, Japan

[5] Natl Cardiovasc Ctr Hosp & Res Inst, Dept Biochem, Suita, Osaka 5658565, Japan

[6] Kurume Univ, Sch Med, Inst Life Sci, Kurume, Fukuoka 8300011, Japan

来源：

INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE | 2011年 / 29卷 / 08期

基金：

日本学术振兴会;

关键词：

Rett syndrome; Ghrelin; Insulin-like growth factor-1; Gastrointestinal problems; Growth failure; GROWTH; NEURONS; MECP2; APPETITE; PEPTIDE;

D O I：

10.1016/j.ijdevneu.2011.07.003

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Most patients with Rett syndrome (RTT) have both gastrointestinal problems and somatic growth failure, including microcephaly. Ghrelin is a peptide hormone involved in growth hormone secretion, interdigestive motility, and feeding behavior. Plasma ghrelin assays have previously been described for other neurodevelopmental disorders. To examine the pathophysiology of RTT, we measured plasma levels of ghrelin in patients with RTT A case-control study examining plasma levels of ghrelin, serum growth hormone, and insulin-like growth factor-1 (IGF-1) was performed on 27 patients with RTT and 53 controls. Plasma levels of total (T)- and octanoyl (O)-ghrelin were significantly lower in patients with RTT than in controls. Plasma levels of T-ghrelin correlated significantly with serum IGF-1 levels and head circumference. Significantly lower levels of plasma T-ghrelin and O-ghrelin were observed in RTT patients with eating difficulties, while lower levels of plasma T-ghrelin were observed in RTT patients with constipation, in comparison to patients without either of these symptoms. Alterations in plasma ghrelin levels may reflect various clinical symptoms and signs in RTT patients, including growth failure, acquired microcephalus, autonomic nerve dysfunction, and feeding difficulties. We describe the role of ghrelin in RTT and suggest this peptide as a novel biological marker in patients with RTT. (C) 2011 ISDN. Published by Elsevier Ltd. All rights reserved.

引用

页码：899 / 902

页数：4

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