A conjugate addition-dipolar cycloaddition approach towards the synthesis of various alkaloids

被引：0
作者：
Flick, Andrew C. [1 ]
Padwa, Albert [1 ]
机构：
[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA
来源：
ARKIVOC | 2011年
基金：
美国国家科学基金会;
关键词：
Conjugate addition; dipolar cycloaddition; oxime; bis(phenylsulfonyl)diene; cascade synthesis; reductive cyclization; alkaloid; ENANTIOPURE N-ACYLDIHYDROPYRIDONES; ASYMMETRIC TOTAL-SYNTHESIS; FORMAL TOTAL-SYNTHESIS; PINNAIC ACID; ANNULATION APPROACH; ORGANIC-SYNTHESIS; NATURAL-PRODUCTS; STEREOCONTROLLED SYNTHESIS; ORGANOMETALLIC REAGENTS; AZASPIROCYCLIC CORE;
D O I：
暂无
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The key element for the synthesis of several alkaloid skeletons consists of a conjugate addition-dipolar cycloaddition of 2,3-bis(phenylsulfonyl)-1,3-butadiene with an appropriate oxime. The resulting cycloadducts are cleaved reductively to provide azapolycyclic scaffolds with strategically placed functionality for further manipulation to the target compounds.
引用
收藏
页码：137 / 161
页数：25
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