A conjugate addition-dipolar cycloaddition approach towards the synthesis of various alkaloids

被引：0

作者：

Flick, Andrew C. ^{[1
]}

Padwa, Albert ^{[1
]}

机构：

[1] Emory Univ, Dept Chem, Atlanta, GA 30322 USA

来源：

ARKIVOC | 2011年

基金：

美国国家科学基金会;

关键词：

Conjugate addition; dipolar cycloaddition; oxime; bis(phenylsulfonyl)diene; cascade synthesis; reductive cyclization; alkaloid; ENANTIOPURE N-ACYLDIHYDROPYRIDONES; ASYMMETRIC TOTAL-SYNTHESIS; FORMAL TOTAL-SYNTHESIS; PINNAIC ACID; ANNULATION APPROACH; ORGANIC-SYNTHESIS; NATURAL-PRODUCTS; STEREOCONTROLLED SYNTHESIS; ORGANOMETALLIC REAGENTS; AZASPIROCYCLIC CORE;

D O I：

暂无

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The key element for the synthesis of several alkaloid skeletons consists of a conjugate addition-dipolar cycloaddition of 2,3-bis(phenylsulfonyl)-1,3-butadiene with an appropriate oxime. The resulting cycloadducts are cleaved reductively to provide azapolycyclic scaffolds with strategically placed functionality for further manipulation to the target compounds.

引用

页码：137 / 161

页数：25

共 182 条

[1] FACILE ROUTE TO 1-PHOSPHORYL-1,3-DIENES AND 1-SULFONYL-1,3-DIENES VIA PALLADIUM-CATALYZED ELIMINATION OF ALLYLIC ACETATES [J].