Hippocampal Atrophy Is Associated with Subjective Memory Decline: The PATH Through Life Study

被引：52
作者：
Cherbuin, Nicolas [1 ]
Sargent-Cox, Kerry [1 ]
Easteal, Simon [2 ]
Sachdev, Perminder [3 ]
Anstey, Kaarin J. [1 ]
机构：
[1] Australian Natl Univ, Ctr Res Ageing Hlth & Wellbeing, Canberra, ACT 0200, Australia
[2] Australian Natl Univ, John Curtin Sch Med Res, Canberra, ACT 0200, Australia
[3] Univ New S Wales, Sch Psychiat, Sydney, NSW, Australia
来源：
AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY | 2015年 / 23卷 / 05期
基金：
澳大利亚研究理事会; 英国医学研究理事会;
关键词：
Cognitive decline; longitudinal; APOE epsilon 4; MRI; MILD COGNITIVE IMPAIRMENT; POPULATION-BASED COHORT; ALZHEIMERS-DISEASE; OLDER-PEOPLE; FOLLOW-UP; COMPLAINTS; COMMUNITY; DEMENTIA; METAANALYSIS; DEPRESSION;
D O I：
10.1016/j.jagp.2014.07.009
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Objective: To investigate whether subjective memory decline (SMD) in cognitively healthy individuals is associated with hippocampal atrophy. Methods: Multiple regression analyses assessing the relationship between hippocampal atrophy over 4 years and SMD at baseline and follow-up in 305 cognitively healthy individuals aged 60-64 years free from dementia, mild cognitive impairment, and other neurological disorders. Results: SMD at baseline was not a significant predictor of hippocampal atrophy. However, SMD at follow-up was associated with greater hippocampal atrophy. Associations were reduced but remained significant after controlling for anxiety and depression symptomatology. Conclusion: Hippocampal atrophy was associated with incident/persisting SMD and this association was not, or only partly, explained by anxiety and depression symptomatology. These results are consistent with a biological origin to subjective memory decline. SMD should be included in screening and neuropsychological batteries.
引用
收藏
页码：446 / 455
页数：10
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