Continuous poly(2-oxazoline) triblock copolymer synthesis in a microfluidic reactor cascade

被引：41

作者：

Baeten, Evelien ^{[1
]}

Verbraeken, Bart ^{[2
]}

Hoogenboom, Richard ^{[2
]}

Junkers, Tanja ^{[1
,3
]}

机构：

[1] Univ Hasselt, Polymer React Design Grp, Inst Mat Res IMO, B-3500 Hasselt, Belgium

[2] Univ Ghent, Supramol Chem Grp, Dept Organ & Macromol Chem, Krijgslaan 291-S4, B-9000 Ghent, Belgium

[3] IMEC Associated Lab IMOMEC, B-3590 Diepenbeek, Belgium

来源：

CHEMICAL COMMUNICATIONS | 2015年 / 51卷 / 58期

关键词：

RING-OPENING POLYMERIZATION; MICROWAVE-ASSISTED POLYMERIZATIONS; BLOCK-COPOLYMERS; SCALE-UP; MODE; MICROREACTOR; FUNCTIONALIZATION;

D O I：

10.1039/c5cc04319k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Cationic ring-opening polymerizations of 2-oxazolines were investigated in continuous microflow reactors. Fast homopolymerizations of 2-ethyl-2-oxazoline (EtOx) and 2-n-propyl-2-oxazoline (nPropOx) were carried out up to 180 degrees C, yielding well-controlled polymers. Also well-defined diblock and triblock copolymers were produced in a microfluidic reactor cascade, demonstrating the high value of microflow synthesis for the built-up of advanced poly(2-oxazoline)-based polymers.

引用

页码：11701 / 11704

页数：4

共 29 条

[1] Poly(2-oxazolines) in biological and biomedical application contexts [J].

Adams, Nico ;

Schubert, Ulrich S. .

ADVANCED DRUG DELIVERY REVIEWS, 2007, 59 (15) :1504-1520

[2] Polymerization of oxazolines [J].

Aoi, K ;

Okada, M .

PROGRESS IN POLYMER SCIENCE, 1996, 21 (01) :151-208

[3] Overcoming the PEG-addiction: well-defined alternatives to PEG, from structure-property relationships to better defined therapeutics [J].

Barz, Matthias ;

Luxenhofer, Robert ;

Zentel, Rudolf ;

Vicent, Maria J. .

POLYMER CHEMISTRY, 2011, 2 (09) :1900-1918

[4] Accelerated pressure synthesis and characterization of 2-oxazoline block copolymers [J].

Hoogenboom, R ;

Fijten, MWM ;

Paulus, RM ;

Thijs, HML ;

Hoeppener, S ;

Kickelbick, G ;

Schubert, US .

POLYMER, 2006, 47 (01) :75-84

[5] Tuning the LCST of poly(2-oxazoline)s by varying composition and molecular weight: alternatives to poly(N-isopropylacrylamide)? [J].

Hoogenboom, Richard ;

Thijs, Hanneke M. L. ;

Jochems, Mark J. H. C. ;

van Lankvelt, Bart M. ;

Fijten, Martin W. M. ;

Schubert, Ulrich S. .

CHEMICAL COMMUNICATIONS, 2008, (44) :5758-5760

[6] Scale-up of microwave-assisted polymerizations in batch mode:: The cationic ring-opening polymerization of 2-ethyl-2-oxazoline [J].

Hoogenboom, Richard ;

Paulus, Renzo M. ;

Pilotti, Ake ;

Schubert, Ulrich S. .

MACROMOLECULAR RAPID COMMUNICATIONS, 2006, 27 (18) :1556-1560

[7] Bioinspired Poly(2-oxazoline)s [J].

Hoogenboom, Richard ;

Schlaad, Helmut .

POLYMERS, 2011, 3 (01) :467-488

[8] RING-OPENING POLYMERIZATION OF 2-SUBSTITUTED 2-OXAZOLINES [J].

KAGIYA, T ;

NARISAWA, S ;

MAEDA, T ;

FUKUI, K .

JOURNAL OF POLYMER SCIENCE PART B-POLYMER LETTERS, 1966, 4 (7PB) :441-&

[9] BLOCK COPOLYMERS FROM CYCLIC IMINO ETHERS - A NEW CLASS OF NONIONIC POLYMER SURFACTANT [J].

KOBAYASHI, S ;

IGARASHI, T ;

MORIUCHI, Y ;

SAEGUSA, T .

MACROMOLECULES, 1986, 19 (03) :535-541

[10]

Lach C, 1998, MACROMOL RAPID COMM, V19, P461, DOI 10.1002/(SICI)1521-3927(19980901)19:9<461::AID-MARC461>3.3.CO

← 1 2 3 →