Light-Triggered Drug Release Platform Based on Superhydrophobicity of Mesoporous Silica Nanoparticles

被引：25
作者：
Gui, Wanyuan [1 ]
Lin, Junpin [1 ]
Hao, Guojian [1 ]
Liang, Yongfeng [1 ]
Wang, Wenqian [2 ]
Wen, Yongqiang [2 ]
机构：
[1] Univ Sci & Technol Beijing, State Key Lab Adv Met & Mat, Beijing 100083, Peoples R China
[2] Univ Sci & Technol Beijing, Dept Chem & Biol Engn, Beijing 100083, Peoples R China
来源：
NANOSCIENCE AND NANOTECHNOLOGY LETTERS | 2016年 / 8卷 / 05期
关键词：
Mesoporous Materials; Superhydrophobic/Superhydrophilic; Light-Responsive; Controlled Release; Sensors; ISSUE-ON REVIEWS; PORE-SIZE; DELIVERY; NANOMEDICINE; CELLS;
D O I：
10.1166/nnl.2016.2158
中图分类号：
TB3 [工程材料学];
学科分类号：
0805 ; 080502 ;
摘要：
A light-triggered drug delivery platform based on mesoporous silica nanoparticles (MSNs) was achieved by controlling the surface state of superhydrophobic/superhydrophilic of MSNs. The modified MSNs with an optimal ratio of octadecyltrichlorosilane (OTS) exhibited superhydrophobic character, which successfully inhibited the loaded cargo molecules-fluorescein release from MSNs. Under a condition of irradiation with a high pressure mercury lamp of 400 W for various time intervals, the decomposition of single molecule layer of OTS caused the MSNs surface changing from a "closed" state to an "open" state, owning to the converting of the surface state from superhydrophobic to superhydrophilic, followed by releasing of the fluorescein from pores of the MSNs. The light stimuli-responsive control delivery platform based on MSNs represents a new system, which is expected to have a promising application in nanomedicine, such as drug delivery for cancer chemotherapy.
引用
收藏
页码：428 / 433
页数：6
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