The MSL complex: juggling RNA-protein interactions for dosage compensation and beyond

被引：46
|
作者：
Keller, Claudia Isabelle [1 ]
Akhtar, Asifa [1 ]
机构：
[1] Max Planck Inst Immunobiol & Epigenet, D-79108 Freiburg, Germany
来源：
CURRENT OPINION IN GENETICS & DEVELOPMENT | 2015年 / 31卷
关键词：
MALE X-CHROMOSOME; HISTONE H4; DROSOPHILA-MELANOGASTER; FUNCTIONAL-INTEGRATION; ACETYLTRANSFERASE MOF; H4K16; ACETYLATION; BARREL DOMAIN; UP-REGULATION; GENES; TRANSCRIPTION;
D O I：
10.1016/j.gde.2015.03.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
The Male Specific Lethal (MSL) complex provides an exquisite example of an epigenetic modulator that is involved in chromosome-wide as well as individual gene regulation in flies and mammals. In this review, we discuss the recent advances in biochemical and structural understanding of the MSL complex modules and how they function in X chromosome regulation in flies. Moreover, we describe possible conserved and dosage compensation-independent functions of the MSL complex with a particular focus on mammalian systems.
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收藏
页码：1 / 11
页数：11
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