Expression of costimulatory molecule B7-H3 and its prognostic implications in human acute leukemia

被引：57

作者：

Hu, Yixin ^{[1
,2
]}

Lv, Xin ^{[1
,3
]}

Wu, Yujie ^{[1
]}

Xu, Ji ^{[1
]}

Wang, Lingling ^{[1
]}

Chen, Weifeng ^{[1
]}

Zhang, Wei ^{[1
]}

Li, Jianyong ^{[1
]}

Zhang, Sujiang ^{[1
]}

Qiu, Hongxia ^{[1
]}

机构：

[1] Nanjing Med Univ, Jiangsu Prov Hosp, Affiliated Hosp 1, Dept Hematol, Nanjing 210029, Jiangsu, Peoples R China

[2] Soochow Univ, Childrens Hosp, Dept Haematol, Suzhou, Peoples R China

[3] Yishui Cent Hosp Linyi, Dept Haematol, Linyi, Shandong, Peoples R China

来源：

Hematology | 2015年 / 20卷 / 04期

基金：

中国国家自然科学基金;

关键词：

Costimulatory molecule; B7-H3; Acute myeloid leukemia; Acute lymphocytic leukemia; Prognosis; ACUTE MYELOID-LEUKEMIA; T-CELL-ACTIVATION; B7; FAMILY; ANTITUMOR IMMUNITY; PANCREATIC-CANCER; CD34; EXPRESSION; PROSTATE-CANCER; CARCINOMA; SURVIVAL; LIGAND;

D O I：

10.1179/1607845414Y.0000000186

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objectives: This study focused on the expression pattern and clinical significance of B7-H3 expression in human acute leukemia. Methods: We systematically analyzed 134 patients with acute myeloid leukemia (101 cases) and acute lymphocytic leukemia (33 cases) by flow cytometry. Results: The frequency of B7-H3(+) cases was 44.8% in total. The B7-H3 expression rate differed from 0% to 74.8% in individual cases. The correlation between B7-H3 expression and traditional prognostic factors, such as age and gender, the white blood cell count was not confirmed. However, B7-H3 had a significant higher expression in CD34(+) cases and high risk karyotypes. Conclusions: Owing to the expression of B7-H3 being statistically relevant in predicting disease progression and a shorter life survival, our results demonstrated that B7-H3 expression in acute leukemia predicts an unfavorable outcome.

引用

页码：187 / 195

页数：9

共 36 条

[1] The control of T cell activation vs. tolerance [J].

Abbas, AK .

AUTOIMMUNITY REVIEWS, 2003, 2 (03) :115-118

[2] T-cell coregulatory molecule expression in urothelial cell carcinoma: Clinicopathologic correlations and association with survival [J].

Boorjian, Stephen A. ;

Sheinin, Yuri ;

Crispen, Paul L. ;

Farmer, Sara A. ;

Lohse, Christine M. ;

Kuntz, Susan M. ;

Leibovich, Bradley C. ;

Kwon, Eugene D. ;

Frank, Igor .

CLINICAL CANCER RESEARCH, 2008, 14 (15) :4800-4808

[3] T-cell Co-regulatory Molecule Expression in Renal Angiomyolipoma and Pulmonary Lymphangioleiomyomatosis [J].

Boorjian, Stephen A. ;

Sheinin, Yuri ;

Crispen, Paul L. ;

Lohse, Christine M. ;

Leibovich, Bradley C. ;

Kwon, Eugene D. .

UROLOGY, 2009, 74 (06) :1359-1364

[4] B7-H3:: A costimulatory molecule for T cell activation and IFN-γ production [J].

Chapoval, AI ;

Ni, J ;

Lau, JS ;

Wilcox, RA ;

Flies, DB ;

Liu, D ;

Dong, HD ;

Sica, GL ;

Zhu, GF ;

Tamada, K ;

Chen, LP .

NATURE IMMUNOLOGY, 2001, 2 (03) :269-274

[5] Anti-tumor immunity in a model of acute myeloid leukemia [J].

Cheuk, Adam T. C. ;

Wells, James W. ;

Chan, Lucas ;

Westwood, Nigel B. ;

Berger, Stuart A. ;

Yagita, Hideo ;

Okumura, Ko ;

Farzaneh, Farzin ;

Mufti, Ghulam J. ;

Guinn, Barbara-Ann .

LEUKEMIA & LYMPHOMA, 2009, 50 (03) :447-454

[6] The B7 family of immune-regulatory ligands [J].

Collins, M ;

Ling, V ;

Carreno, BM .

GENOME BIOLOGY, 2005, 6 (06)

[7] Tumor cell and tumor vasculature expression of B7-H3 predict survival in clear cell renal cell carcinoma [J].

Crispen, Paul L. ;

Sheinin, Yuri ;

Roth, Timothy J. ;

Lohse, Christine M. ;

Kuntz, Susan M. ;

Frigola, Xavier ;

Thompson, R. Houston ;

Boorjian, Stephen A. ;

Dong, Haidong ;

Leibovich, Bradley C. ;

Blute, Michael L. ;

Kwon, Eugene D. .

CLINICAL CANCER RESEARCH, 2008, 14 (16) :5150-5157

[8] Detection of CD34, TdT, CD56, CD2, CD4, and CD14 by Flow Cytometry Is Associated With NPM1 and FLT3 Mutation Status in Cytogenetically Normal Acute Myeloid Leukemia [J].

Dalal, Bakul I. ;

Mansoor, Soudeh ;

Manna, Mita ;

Pi, Steven ;

Di Sauro, Giovanna ;

Hogge, Donna E. .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2012, 12 (04) :274-279

[9] Acute myeloid leukemia: 2012 update on diagnosis, risk stratification, and management [J].

Estey, Elihu H. .

AMERICAN JOURNAL OF HEMATOLOGY, 2012, 87 (01) :90-99

[10] CHROMOSOME-ABERRATIONS IN CD34-POSITIVE ACUTE MYELOID-LEUKEMIA - CORRELATION WITH CLINICOPATHOLOGICAL FEATURES [J].

FAGIOLI, F ;

CUNEO, A ;

CARLI, MG ;

BARDI, A ;

PIVA, N ;

PREVIATI, R ;

RIGOLIN, GM ;

FERRARI, L ;

SPANEDDA, R ;

CASTOLDI, G .

CANCER GENETICS AND CYTOGENETICS, 1993, 71 (02) :119-124

← 1 2 3 4 →