Aberrant trafficking of transmembrane proteins in human disease

被引：35
作者：
Cobbold, C
Monaco, AP
Sivaprasadarao, A
Ponnambalam, S [1 ]
机构：
[1] Univ Leeds, Sch Biochem & Mol Biol, Leeds LS2 9JT, W Yorkshire, England
[2] Wellcome Trust Ctr Human Genet, Oxford OX3 7BN, England
[3] Univ Leeds, Sch Biomed Sci, Leeds LS2 9JT, W Yorkshire, England
来源：
TRENDS IN CELL BIOLOGY | 2003年 / 13卷 / 12期
基金：
英国惠康基金; 英国医学研究理事会;
关键词：
D O I：
10.1016/j.tcb.2003.10.008
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Transmembrane domain (TMD) proteins comprise a major group of proteins that perform a wide range of functions and act to translate extracellular signals to intracellular responses. They include G-protein coupled receptors (GPCRs), growth factor receptors, ion channels, transporters and metabolic enzymes. In this review, we focus on the current understanding of trafficking of mutant membrane proteins in human disease and speculate on therapeutic strategies.
引用
收藏
页码：639 / 647
页数：9
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