Differential expression of rat brain Bcl-2 family proteins in development and aging

被引：57

作者：

Shimohama, S ^{[1
]}

Fujimoto, S

Sumida, Y

Tanino, H

机构：

[1] Kyoto Univ, Fac Med, Dept Neurol, Sakyo Ku, Kyoto 606, Japan

[2] Kyoto Pharmaceut Univ, Dept Environm Biochem, Kyoto 607, Japan

来源：

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS | 1998年 / 252卷 / 01期

关键词：

D O I：

10.1006/bbrc.1998.9577

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have previously examined the involvement of the B cell leukemia-2 gene product (Bcl-2) family proteins (Bcl-2, Bcl-x, Bax, Bak, and Bad) in Alzheimer's disease (AD) and found that Bcl-2, Bcl-x, Bak, and Bad were upregulated. As AD is an aging-associated disease, in the present study we examined the developmental and aging-related changes in Bcl-2 family proteins in the rat brain. Immunoblot analyses of brain extracts from embryonic day 19 (E19) to postnatal 96-week-old rats indicated that the Bcl-2 protein level was highest at E19 and decreased after birth. Bcl-x levels remained high from E19 to 96 weeks. Bax levels were high hom E19 to 2 weeks and decreased from 4 weeks onward. Bak levels were highest at E19 and decreased abruptly after birth. Bad levels were high from E19 to 2 weeks and decreased abruptly at 4 weeks. The present results suggest that the expression of each Bcl-2 family protein is differentially regulated during development and aging and that the changes in the senescent brains are different from those observed in AD. (C) 1998 Academic Press.

引用

页码：92 / 96

页数：5

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