The potential role of exosomes in the diagnosis and therapy of ischemic diseases

被引：23

作者：

Wang, Wenting ^{[1
]}

Li, Zijian ^{[1
]}

Feng, Juan ^{[1
]}

机构：

[1] China Med Univ, Shengjing Hosp, Dept Neurol, Shenyang, Liaoning, Peoples R China

来源：

CYTOTHERAPY | 2018年 / 20卷 / 10期

基金：

中国国家自然科学基金;

关键词：

diagnosis; exosomes; ischemia; myocardial infarction; stroke; therapeutics; MESENCHYMAL STEM-CELLS; PLATELET-DERIVED MICROPARTICLES; CIRCULATING ENDOTHELIAL MICROPARTICLES; ACUTE MYOCARDIAL-INFARCTION; CHRONIC HEART-FAILURE; PROGENITOR CELLS; STROMAL CELLS; FUNCTIONAL RECOVERY; CARDIAC-FUNCTION; ISCHEMIA/REPERFUSION INJURY;

D O I：

10.1016/j.jcyt.2018.06.012

中图分类号：

Q813 [细胞工程];

学科分类号：

摘要：

In the past, exosomes have been thought of as cellular dust. Today, they are thought to be carriers of real biomarkers and intercellular biological information. The composition of exosomes differs according to their source, and the subsequent information they carry, such as protein, microRNA or mRNA, may also be different. Recent studies have demonstrated that exosomes in ischemic diseases can help to make an early diagnosis, and in cellular experiments and animal models, exosomes promote angiogenesis, restrain cell apoptosis and reduce inflammation, among other actions, to protect ischemic organs. There is evidence that these protective effects are related to microRNAs in exosomes. In this review, we discuss the use of exosomes for early diagnosis of ischemic diseases and recent advances in the therapeutic use of exosomes in cell and mammalian models of ischemic diseases.

引用

页码：1204 / 1219

页数：16

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