Molecular Mechanistic Pathways Targeted by Natural Antioxidants in the Prevention and Treatment of Chronic Kidney Disease

被引:17
作者
Mohany, Mohamed [1 ]
Ahmed, Mohammed M. [1 ]
Al-Rejaie, Salim S. [1 ]
机构
[1] King Saud Univ, Coll Pharm, Dept Pharmacol & Toxicol, Riyadh 1145, Saudi Arabia
关键词
chronic kidney disease (CKD); diabetic nephropathy; renal fibrosis; natural compounds; mechanistic pathways; TRADITIONAL CHINESE MEDICINE; GRAPE SEED PROANTHOCYANIDINS; AMELIORATES RENAL FIBROSIS; FLOS-ABELMOSCHUS-MANIHOT; GROWTH-FACTOR-BETA; FACTOR-KAPPA-B; OXIDATIVE STRESS; URSOLIC ACID; DIABETIC-NEPHROPATHY; BETULINIC ACID;
D O I
10.3390/antiox11010015
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Chronic kidney disease (CKD) is the progressive loss of renal function and the leading cause of end-stage renal disease (ESRD). Despite optimal therapy, many patients progress to ESRD and require dialysis or transplantation. The pathogenesis of CKD involves inflammation, kidney fibrosis, and blunted renal cellular antioxidant capacity. In this review, we have focused on in vitro and in vivo experimental and clinical studies undertaken to investigate the mechanistic pathways by which these compounds exert their effects against the progression of CKD, particularly diabetic nephropathy and kidney fibrosis. The accumulated and collected data from preclinical and clinical studies revealed that these plants/bioactive compounds could activate autophagy, increase mitochondrial bioenergetics and prevent mitochondrial dysfunction, act as modulators of signaling pathways involved in inflammation, oxidative stress, and renal fibrosis. The main pathways targeted by these compounds include the canonical nuclear factor kappa B (NF-kappa B), canonical transforming growth factor-beta (TGF-beta), autophagy, and Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor erythroid factor 2-related factor 2 (Nrf2)/antioxidant response element (ARE). This review presented an updated overview of the potential benefits of these antioxidants and new strategies to treat or reduce CKD progression, although the limitations related to the traditional formulation, lack of standardization, side effects, and safety.
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页数:33
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共 258 条
  • [31] Treatment of chronic kidney disease using a traditional Chinese medicine, Flos Abelmoschus manihot (Linnaeus) Medicus (Malvaceae)
    Chen, Yizhi
    Cai, Guangyan
    Sun, Xuefeng
    Chen, Xiangmei
    [J]. CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 2016, 43 (02): : 145 - 148
  • [32] Chtourou Y, 2016, FOOD FUNCT, V7, P183, DOI [10.1039/c5fo00871a, 10.1039/C5FO00871A]
  • [33] Therapeutic Properties of Bioactive Compounds from Different Honeybee Products
    Cornara, Laura
    Biagi, Marco
    Xiao, Jianbo
    Burlando, Bruno
    [J]. FRONTIERS IN PHARMACOLOGY, 2017, 8
  • [34] Antidiabetic Properties of Naringenin: A Citrus Fruit Polyphenol
    Den Hartogh, Danja J.
    Tsiani, Evangelia
    [J]. BIOMOLECULES, 2019, 9 (03):
  • [35] Anti-hyperglycemic effects and mechanism of traditional Chinese medicine Huanglian Wan in streptozocin-induced diabetic rats
    Deng, Yuan-xiong
    Zhang, Xiao-jie
    Shi, Qun-zhi
    Chen, Yu-shuang
    Qiu, Xi-min
    Chen, Bo
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2012, 144 (02) : 425 - 432
  • [36] The Evolving Role of TRAFs in Mediating Inflammatory Responses
    Dhillon, Bipandeep
    Aleithan, Fatemah
    Abdul-Sater, Zahi
    Abdul-Sater, Ali A.
    [J]. FRONTIERS IN IMMUNOLOGY, 2019, 10
  • [37] Astragalus propinquus Schischkin and Panax notoginseng (A&P) compound relieved cisplatin-induced acute kidney injury through inhibiting the mincle maintained macrophage inflammation
    Diao Hui
    Tan Rui-Zhi
    Li Jian-Chun
    Zhong Xia
    Wen Dan
    Fan Jun-Ming
    Wang Li
    [J]. JOURNAL OF ETHNOPHARMACOLOGY, 2020, 252
  • [38] Activation of 20-HETE/PPARs involved in reno-therapeutic effect of naringenin on diabetic nephropathy
    Ding, Shumei
    Qiu, Hongmei
    Huang, Jiajun
    Chen, Rongchun
    Zhang, Jie
    Huang, Bo
    Zou, Xunliang
    Cheng, Oumei
    Jiang, Qingsong
    [J]. CHEMICO-BIOLOGICAL INTERACTIONS, 2019, 307 : 116 - 124
  • [39] Autophagy in diabetic nephropathy
    Ding, Yan
    Choi, Mary E.
    [J]. JOURNAL OF ENDOCRINOLOGY, 2015, 224 (01) : R15 - R30
  • [40] Protective Effects of Grape Seed Proanthocyanidins on the Kidneys of Diabetic Rats through the Nrf2 Signalling Pathway
    Ding, Yusong
    Li, Haiyan
    Li, Yang
    Liu, Dandan
    Zhang, Liyuan
    Wang, Tongling
    Liu, Tao
    Ma, Long
    [J]. EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2020, 2020