Outcome of Wingspan Stent Using Aggressive Post-stent Balloon Dilation for Intracranial Atherosclerosis Stenosis

Background: Wingspan stent has gained interest for better long-term outcomes for intracranial atherosclerosis disease (ICAD). However, in-stent restenosis still presents as a problem and may cause postoperative neurological events. We aimed to find a way to prevent in-stent restenosis Method: Patients with stenosis >70% ICAD were treated with wingspan stent and were retrospectively reviewed. The patients were separated into two groups: one with post-dilation and the other without post-dilation. The outcomes of wingspan stenting were compared immediately after the surgery and at a 1-year follow-up. Results: Overall, 28 patients were included for analysis, with 15 patients undergoing post-dilation and 13 patients not undergoing the procedure. The extent of stenosis was significantly lower in the post-dilation group than in the no post-dilation group, both immediately after the surgery (14.8 +/- 10.2 vs. 28.5 +/- 14.5%, p < 0.01) and at 1-year follow-up (25.8 +/- 18.0 vs. 50.1 +/- 23.2%, p < 0.01). The post-dilation method immediately expanded the stent diameter (2.89 +/- 0.48 vs. 3.05 +/- 0.44 mm, p < 0.001), and the diameter still increased at 1-year follow-up (3.05 +/- 0.44 vs. 3.12 +/- 0.43 mm, p < 0.01) due to the self-expandable property of the wingspan. Similarly, in the no post-dilation group, the stent size was also increased (2.70 +/- 0.67 vs. 2.80 +/- 0.64 mm, p < 0.01). However, at 1-year follow up, the luminal diameter was stationary in the post-dilation group (2.36 +/- 0.73 vs. 2.46 +/- 0.82 mm, p = 0.88) and decreased in the no post-dilation group (2.24 +/- 0.56 vs. 1.60 +/- 0.79 mm, p < 0.01). The periprocedural complication rate was similar between the groups. Conclusion: The post-dilation method can be feasibly performed and can offer better stent expansion and apposition in the wingspan system. By applying this technique, we might prevent in-stent restenosis and improve neurological outcomes.