Genome engineering in rodents - status quo and perspectives

被引：1
作者：
Kuehn, Ralf [1 ]
机构：
[1] Max Delbruck Ctr Mol Med Helmholtz Assoc MDC, Robert Rossle Str 10, D-13125 Berlin, Germany
来源：
LABORATORY ANIMALS | 2022年 / 56卷 / 01期
关键词：
CRISPR; mouse; rat; rodents; genetics; gene editing; genome editing; animal models; ONE-STEP GENERATION; MOUSE GENOME; KNOCKIN MICE; EFFICIENT; ELECTROPORATION; RIBONUCLEOPROTEIN; EXPRESSION; ZYGOTES; GENES;
D O I：
10.1177/00236772211051842
中图分类号：
S85 [动物医学（兽医学）];
学科分类号：
0906 ;
摘要：
The introduction of the CRISPR-Cas9 system in 2013 has revolutionized experimental genetics in mice and rats. This commentary gives an overview on the use of CRISPR either for gene editing in the germline or for editing and beyond editing in somatic cells. Future perspectives are opened by emerging CRISPR technologies that could enable genome engineering at larger scale.
引用
收藏
页码：83 / 87
页数：5
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