Label Free DNA Detection Using Large Area Graphene Based Field Effect Transistor Biosensors

被引：54

作者：

Guo, Shi-Rui ^{[2
]}

Lin, Jian ^{[3
]}

Penchev, Miroslav ^{[4
]}

Yengel, Emre ^{[4
]}

Ghazinejad, Maziar ^{[3
]}

Ozkan, Cengiz S. ^{[1
,2
]}

Ozkan, Mihrimah ^{[3
]}

机构：

[1] Univ Calif Riverside, Mat Sci & Engn Program, Riverside, CA 92521 USA

[2] Univ Calif Riverside, Dept Chem, Riverside, CA 92521 USA

[3] Univ Calif Riverside, Dept Mech Engn, Riverside, CA 92521 USA

[4] Univ Calif Riverside, Dept Elect Engn, Riverside, CA 92521 USA

来源：

JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY | 2011年 / 11卷 / 06期

关键词：

DNA; Biosensor; FET; Functionalization; Non-Covalent; ELECTRICAL DETECTION; LAYER GRAPHENE; CARBON; SENSORS;

D O I：

10.1166/jnn.2011.3885

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

We describe the fabrication of highly sensitive graphene based field effect transistor (FET) biosensors with a cost-effective approach and their application in label-free Deoxyribonucleic acid (DNA) detection. Chemical vapor deposition (CVD) grown graphene layers were used to achieve mass production of FET devices via conventional photolithographic patterning. Non-covalent functionalization of the graphene layer with 1-Pyrenebutanoic acid succinimidyl ester ensures high conductivity and sensitivity of the FET device. The present device could reach a detection limit as low as 3 X 10(-9) M.

引用

页码：5258 / 5263

页数：6

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