The Impact of m1A Methylation Modification Patterns on Tumor Immune Microenvironment and Prognosis in Oral Squamous Cell Carcinoma

被引：23

作者：

Gao, Li ^{[1
]}

Chen, Ru ^{[2
]}

Sugimoto, Masahiro ^{[3
]}

Mizuta, Masanobu ^{[1
]}

Kishimoto, Yo ^{[1
]}

Omori, Koichi ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Med, Dept Otolaryngol Head & Neck Surg, Kyoto 6068507, Japan

[2] Matsusaka City Hosp, Matsusaka 5158544, Japan

[3] Tokyo Med Univ, Ctr Minimally Invas Therapies, Inst Med Sci Res & Dev, Tokyo 1608402, Japan

来源：

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2021年 / 22卷 / 19期

基金：

日本学术振兴会;

关键词：

N1-methyladenosine (m1A) modification; oral squamous cell carcinoma; tumor immune microenvironment; prognosis; MESSENGER-RNA; CANCER; METHYLTRANSFERASE; HEAD; CHEMOTHERAPY; LYMPHOCYTES; LANDSCAPE; METHYLOME; RECURRENT;

D O I：

10.3390/ijms221910302

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

N1-methyladenosine (m1A) modification widely participates in the occurrence and progression of numerous diseases. Nevertheless, the potential roles of m1A in the tumor immune microenvironment (TIME) are still not fully understood. Based on 10 m1A methylation regulators, we comprehensively explored the m1A modification patterns in 502 patients with oral squamous cell carcinoma (OSCC). The m1A modification patterns were correlated with TIME characteristics and the m1A score was established to evaluate the effect of the m1A modification patterns on individual OSCC patients. The TIME characteristics and survival outcomes under the three m1A modification patterns were significantly distinct. OSCC patients in the high m1A score group were characterized by poorer prognosis, lower immune infiltration, lower ssGSEA score, lower expression levels of immune checkpoint molecules, and higher tumor mutation loads. The present study revealed that m1A modification might be associated with the TIME in OSCC, and has potential predictive ability for the prognosis of OSCC.

引用

页数：17

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