Lipid nanocarriers for the loading of polyphenols - A comprehensive review

被引：97

作者：

Pimentel-Moral, S. ^{[1
,2
,3
]}

Teixeira, M. C. ^{[3
,4
]}

Fernandes, A. R. ^{[3
,4
]}

Arraez-Roman, D. ^{[1
,2
]}

Martinez-Ferez, A. ^{[5
]}

Segura-Carretero, A. ^{[1
,2
]}

Souto, E. B. ^{[3
,4
]}

机构：

[1] Univ Granada, Dept Analyt Chem, E-18071 Granada, Spain

[2] Res & Dev Ctr Funct Food CIDAF, Hlth Sci Technol Pk, Granada 18016, Spain

[3] Univ Coimbra FFUC, Dept Pharmaceut Technol, Fac Pharm, P-3000548 Coimbra, Portugal

[4] Univ Coimbra, Fac Pharm, Grp Pharmaceut Technol, REQUIMTE LAQV, Coimbra, Portugal

[5] Univ Granada, Chem Engn Dept, E-18071 Granada, Spain

来源：

ADVANCES IN COLLOID AND INTERFACE SCIENCE | 2018年 / 260卷

关键词：

Polyphenols; Lipids; Nanoencapsulation; Bioavailability; Neurodegenerative diseases; Antioxidant; NANOPARTICLES EGCG-LNS; GREEN TEA POLYPHENOL; EPIGALLOCATECHIN GALLATE; IN-VITRO; PHOSPHOLIPID COMPLEX; CORE NANOCAPSULES; DELIVERY-SYSTEMS; LIPOSOMES; CURCUMIN; BIOAVAILABILITY;

D O I：

10.1016/j.cis.2018.08.007

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

Polyphenols are secondary metabolites found in all vascular plants and constitute a large group of at least 10,000 unique compounds. Particular attention is currently being paid to polyphenols attributed to their beneficial effects in the protection and prevention of several diseases. While their use in food, pharmaceutical and cosmetic industries is largely documented, several environmental conditions (e.g. light, temperature or oxygen) may affect the physicochemical stability of polyphenols, compromising their bioactivity in vivo. To overcome these limitations, the loading of polyphenols into nanoparticles has been proposed aiming at both increasing their bioavailability and reducing eventual side effects. Lipid nanoparticles offer several advantages, namely their biodegradability and low toxicity, with the additional capacity to modify the release profile of loaded drugs. This paper is a review of the recent advances of lipid nanocarriers commonly used for the encapsulation of poly phenols, highlighting their added value to increase bioavailability and bioactivity of this group of compounds as well as their application in several diseases. (C) 2018 Elsevier B.V. All rights reserved.

引用

页码：85 / 94

页数：10

共 99 条

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