The NOTCH1/CD39 axis: a Treg trip-switch for GvHD

被引：12

作者：

Del Papa, B. ^{[1
]}

Pierini, A. ^{[1
,2
]}

Sportoletti, P. ^{[1
]}

Baldoni, S. ^{[3
]}

Cecchini, D. ^{[1
]}

Rosati, E. ^{[4
]}

Dorillo, E. ^{[1
]}

Aureli, P. ^{[1
]}

Zei, T. ^{[1
]}

Ostini, R. Iacucci ^{[1
]}

Ruggeri, L. ^{[1
]}

Carotti, A. ^{[1
]}

Velardi, A. ^{[1
]}

Negrin, R. ^{[2
]}

Martelli, M. F. ^{[1
]}

Falzetti, F. ^{[1
]}

Di Ianni, M. ^{[3
]}

机构：

[1] Univ Perugia, Div Hematol & Clin Immunol, Dept Med, Perugia, Italy

[2] Stanford Univ, Dept Med, Div Blood & Marrow Transplantat, Stanford, CA 94305 USA

[3] Univ Aquila, Hematol Sect, Dept Life Hlth & Environm Sci, Laquila, Italy

[4] Univ Perugia, Biosci & Med Embryol Sect, Dept Expt Med, Perugia, Italy

来源：

LEUKEMIA | 2016年 / 30卷 / 09期

关键词：

VERSUS-HOST-DISEASE; REGULATORY T-CELLS; BONE-MARROW-TRANSPLANTATION; CD4(+); ATP; SUPPRESSION; EXPRESSION; SEPARATION; RESPONSES;

D O I：

10.1038/leu.2016.87

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

引用

页码：1931 / 1934

页数：4

共 21 条

[1]

[Anonymous], BLOOD

[2] Expression of ectonucleotidase CD39 by Foxp3+ Treg cells:: hydrolysis of extracellular ATP and immune suppression [J].

Borsellino, Giovanna ;

Kleinewietfeld, Markus ;

Di Mitri, Diletta ;

Sternjak, Alexander ;

Diamantini, Adamo ;

Giometto, Raffaella ;

Hoepner, Sabine ;

Centonze, Diego ;

Bernardi, Giorgio ;

Dell'Acqua, Maria Luisa ;

Rossini, Paolo Maria ;

Battistini, Luca ;

Rotzschke, Olaf ;

Falk, Kirsten .

BLOOD, 2007, 110 (04) :1225-1232

[3] Mecnanisms underlying CD4+Treg immune regulation in the adult: from experiments to models [J].

Caridade, Marta ;

Grace, Luis ;

Ribeiro, Ruy M. .

FRONTIERS IN IMMUNOLOGY, 2013, 4

[4] An experimental model of idiopathic pneumonia syndrome after bone marrow transplantation .1. The roles of minor H antigens and endotoxin [J].

Cooke, KR ;

Kobzik, L ;

Martin, TR ;

Brewer, J ;

Delmonte, J ;

Crawford, JM ;

Ferrara, JLM .

BLOOD, 1996, 88 (08) :3230-3239

[5] Immunomagnetic isolation of CD4+CD25+FoxP3+ natural T regulatory lymphocytes for clinical applications [J].

Di Ianni, M. ;

Del Papa, B. ;

Cecchini, D. ;

Bonifacio, E. ;

Moretti, L. ;

Zei, T. ;

Ostini, R. Iacucci ;

Falzetti, F. ;

Fontana, L. ;

Tagliapietra, G. ;

Maldini, C. ;

Martelli, M. F. ;

Tabilio, A. .

CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2009, 156 (02) :246-253

[6] T regulatory cell separation for clinical application [J].

Di Ianni, Mauro ;

Del Papa, Beatrice ;

Zei, Tiziana ;

Ostini, Roberta Iacucci ;

Cecchini, Debora ;

Cantelmi, Maria Grazia ;

Baldoni, Stefano ;

Sportoletti, Paolo ;

Cavalli, Laura ;

Carotti, Alessandra ;

Pierini, Antonio ;

Falini, Brunangelo ;

Martelli, Massimo F. ;

Falzetti, Franca .

TRANSFUSION AND APHERESIS SCIENCE, 2012, 47 (02) :213-216

[7] Immunoselection and clinical use of T regulatory cells in HLA-haploidentical stem cell transplantation [J].

Di Ianni, Mauro ;

Falzetti, Franca ;

Carotti, Alessandra ;

Terenzi, Adelmo ;

Del Papa, Beatrice ;

Perruccio, Katia ;

Ruggeri, Loredana ;

Sportoletti, Paolo ;

Rosati, Emanuela ;

Marconi, Pierfrancesco ;

Falini, Brunangelo ;

Reisner, Yair ;

Velardi, Andrea ;

Aversa, Franco ;

Martelli, Massimo F. .

BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY, 2011, 24 (03) :459-466

[8] CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation [J].

Edinger, M ;

Hoffmann, P ;

Ermann, J ;

Drago, K ;

Fathman, CG ;

Strober, S ;

Negrin, RS .

NATURE MEDICINE, 2003, 9 (09) :1144-1150

[9] Graft versus host disease: New insights into A2A receptor agonist therapy [J].

Jones, Karlie R. ;

Kang, Elizabeth M. .

COMPUTATIONAL AND STRUCTURAL BIOTECHNOLOGY JOURNAL, 2015, 13 :101-105

[10] Mitochondria Are Gate-keepers of T Cell Function by Producing the ATP That Drives Purinergic Signaling [J].

Ledderose, Carola ;

Bao, Yi ;

Lidicky, Markus ;

Zipperle, Johannes ;

Li, Linglin ;

Strasser, Katharina ;

Shapiro, Nathan I. ;

Junger, Wolfgang G. .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2014, 289 (37) :25936-25945

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