MODULATION OF NF-KB SIGNALLING PATHWAYS BY PARASITES

被引：0

作者：

Symeonidou, I. ^{[1
]}

Kourelis, A. ^{[2
]}

Frydas, I. ^{[1
]}

Karagouni, E. ^{[3
]}

Anogeianaki, A. ^{[4
]}

Hatzistilianou, M. ^{[5
]}

Frydas, S. ^{[1
]}

机构：

[1] Aristotle Univ Thessaloniki, Sch Vet Med, Lab Parasitol & Parasit Dis, Thessaloniki 54124, Greece

[2] Aristotle Univ Thessaloniki, Sch Biol, Dept Genet Dev & Mol Biol, Thessaloniki 54124, Greece

[3] Inst Pasteur Hellen, Cellular Immunol Lab, Athens, Greece

[4] Aristotle Univ Thessaloniki, Sch Med, Dept Physiol, Thessaloniki 54124, Greece

[5] Aristotle Univ Thessaloniki, Sch Med, Dept Pediat 2, Thessaloniki 54124, Greece

来源：

JOURNAL OF BIOLOGICAL REGULATORS AND HOMEOSTATIC AGENTS | 2010年 / 24卷 / 04期

关键词：

NF-kappa B signalling pathways; parasites; FACTOR-KAPPA-B; TOXOPLASMA-GONDII INFECTION; HOST-PATHOGEN INTERACTIONS; IN-VITRO; INFLAMMATORY CYTOKINES; RHEUMATOID-ARTHRITIS; MULTIPLE-SCLEROSIS; GENE-EXPRESSION; DENDRITIC CELLS; IFN-GAMMA;

D O I：

暂无

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

NF-kappa B is implicated in lymphocyte development, maturation, proliferation and survival. This inducible transcription factor is widely expressed by virtually all cell types. In mammals, the genes rela, relb, crel, nf kappa B1, and nf kappa B2 encode the five NF-kappa B protein family members RelA (p65), RelB, c-Rel, p50, and 1352, respectively, which form homo- and heterodimeric DNA-binding complexes capable of regulating target gene transcription of specific biological responses differentially. NF-kappa B regulates the expression of a wide variety of genes that play critical roles in innate and adaptive immune responses, is strongly linked to the inhibition of apoptosis, and contributes to tumor growth, metastasis, and chemoresistance. Parasites have targeted several parts of the NF-kappa B pathway, allowing them to interfere with the transcription of immune response genes. The biology of different parasites is critical in influencing the patterns and kinetics of NF-kappa B activity and thereby the development of subsequent immune responses.

引用

页码：471 / 479

页数：9