Synthesis and Diversification of 1,2,3-Triazole-Fused 1,4-Benzodiazepine Scaffolds

被引：87
|
作者：
Donald, James R. [1 ]
Martin, Stephen F. [1 ]
机构：
[1] Univ Texas Austin, Dept Chem & Biochem, Texas Inst Drug & Diagnost Dev, Austin, TX 78712 USA
来源：
ORGANIC LETTERS | 2011年 / 13卷 / 05期
基金：
美国国家卫生研究院;
关键词：
DIVERSE HETEROCYCLIC SCAFFOLDS; PRIVILEGED STRUCTURES; MULTICOMPONENT REACTIONS; DRUG DISCOVERY; ANTAGONISTS; CONDENSATION; ANTHRAMYCIN; DERIVATIVES; CHEMISTRY; DESIGN;
D O I：
10.1021/ol1028404
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A substituted heterocyclic scaffold comprising a 1,4-benzodiazepine fused with a 1,2,3-triazole ring has been synthesized and diversified via a variety of refunctionalizations. The strategy features the rapid assembly of the scaffold by combining 3-4 reactants in an efficient multicomponent assembly process, followed by an intramolecular Huisgen cycloaddition.
引用
收藏
页码：852 / 855
页数：4
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