Synthesis and Diversification of 1,2,3-Triazole-Fused 1,4-Benzodiazepine Scaffolds

被引：87

作者：

Donald, James R. ^{[1
]}

Martin, Stephen F. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Chem & Biochem, Texas Inst Drug & Diagnost Dev, Austin, TX 78712 USA

来源：

ORGANIC LETTERS | 2011年 / 13卷 / 05期

基金：

美国国家卫生研究院;

关键词：

DIVERSE HETEROCYCLIC SCAFFOLDS; PRIVILEGED STRUCTURES; MULTICOMPONENT REACTIONS; DRUG DISCOVERY; ANTAGONISTS; CONDENSATION; ANTHRAMYCIN; DERIVATIVES; CHEMISTRY; DESIGN;

D O I：

10.1021/ol1028404

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A substituted heterocyclic scaffold comprising a 1,4-benzodiazepine fused with a 1,2,3-triazole ring has been synthesized and diversified via a variety of refunctionalizations. The strategy features the rapid assembly of the scaffold by combining 3-4 reactants in an efficient multicomponent assembly process, followed by an intramolecular Huisgen cycloaddition.

引用

页码：852 / 855

页数：4

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